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The gene expression analysis of blood reveals S100A11 and AQP9 as potential biomarkers of infective endocarditis
- Source :
- PLoS ONE, PLoS ONE, 2012, 7 (2), pp.e31490. ⟨10.1371/journal.pone.0031490⟩, PLoS ONE, Public Library of Science, 2012, 7 (2), pp.e31490. ⟨10.1371/journal.pone.0031490⟩, PLoS ONE, Vol 7, Iss 2, p e31490 (2012)
- Publication Year :
- 2011
-
Abstract
- International audience; Background: The diagnostic and prognostic assessments of infective endocarditis (IE) are challenging. To investigate the host response during IE and to identify potential biomarkers, we determined the circulating gene expression profile using whole genome microarray analysis.Methods and Results: A transcriptomic case-control study was performed on blood samples from patients with native valve IE (n = 39), excluded IE after an initial suspicion (n = 10) at patient's admission, and age-matched healthy controls (n = 10). Whole genome microarray analysis showed that patients with IE exhibited a specific transcriptional program with a predominance of gene categories associated with cell activation as well as innate immune and inflammatory responses. Quantitative real-time RT-PCR performed on a selection of highly modulated genes showed that the expression of the gene encoding S100 calcium binding protein A11 (S100A11) was significantly increased in patients with IE in comparison with controls (P
- Subjects :
- Bacterial Diseases
Critical Care and Emergency Medicine
Microarrays
Science
Staphylococcus
Serum proteins
Cardiovascular
Aquaporins
[SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system
Genome Analysis Tools
[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases
[SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN]
Pathology
Humans
Biology
Inflammation
Heart Failure
Endocarditis
Gene Expression Profiling
S100 Proteins
Computational Biology
Genomics
Blood Proteins
Diagnostic medicine
Up-Regulation
Infectious Diseases
Case-Control Studies
Medicine
Gene expression
Biomarkers
Research Article
General Pathology
Subjects
Details
- ISSN :
- 19326203
- Volume :
- 7
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- PloS one
- Accession number :
- edsair.pmid.dedup....7bbf13811552d98144866b761bfe5bab