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Guidance Level for Brevetoxins in French Shellfish
- Source :
- Marine Drugs, Marine drugs, Marine drugs, 2021, 19 (9), pp.520. ⟨10.3390/md19090520⟩, Marine drugs, MDPI, 2021, 19 (9), pp.520. ⟨10.3390/md19090520⟩, Marine Drugs (1660-3397) (MDPI AG), 2021-09, Vol. 19, N. 9, P. 520 (15p.), Marine Drugs, Vol 19, Iss 520, p 520 (2021)
- Publication Year :
- 2021
-
Abstract
- To prevent health risks associated with the consumption of shellfish contaminated with BTXs in France, a working group was set up by the French Agency for Food, Environmental and Occupational Health & Safety (Anses). One of the aims of this working group was to propose a guidance level for the presence of BTXs in shellfish.; International audience; Brevetoxins (BTXs) are marine biotoxins responsible for neurotoxic shellfish poisoning (NSP) after ingestion of contaminated shellfish. NSP is characterized by neurological, gastrointestinal and/or cardiovascular symptoms. The main known producer of BTXs is the dinoflagellate Karenia brevis, but other microalgae are also suspected to synthesize BTX-like compounds. BTXs are currently not regulated in France and in Europe. In November 2018, they have been detected for the first time in France in mussels from a lagoon in the Corsica Island (Mediterranean Sea), as part of the network for monitoring the emergence of marine biotoxins in shellfish. To prevent health risks associated with the consumption of shellfish contaminated with BTXs in France, a working group was set up by the French Agency for Food, Environmental and Occupational Health & Safety (Anses). One of the aims of this working group was to propose a guidance level for the presence of BTXs in shellfish. Toxicological data were too limited to derive an acute oral reference dose (ARfD). Based on human case reports, we identified two lowest-observed-adverse-effect levels (LOAELs). A guidance level of 180 µg BTX-3 eq./kg shellfish meat is proposed, considering a protective default portion size of 400 g shellfish meat.
- Subjects :
- guidance level
QH301-705.5
Oxocins
food and beverages
[SDV.TOX.TCA]Life Sciences [q-bio]/Toxicology/Toxicology and food chain
Article
[SDV.AEN] Life Sciences [q-bio]/Food and Nutrition
brevetoxins
shellfish
[SDV.TOX.TCA] Life Sciences [q-bio]/Toxicology/Toxicology and food chain
Dinoflagellida
Mediterranean Sea
emerging toxins
Animals
Humans
Shellfish Poisoning
marine biotoxins
Marine Toxins
France
Biology (General)
neurotoxic shellfish poisoning
[SDV.AEN]Life Sciences [q-bio]/Food and Nutrition
Environmental Monitoring
Subjects
Details
- ISSN :
- 16603397
- Volume :
- 19
- Issue :
- 9
- Database :
- OpenAIRE
- Journal :
- Marine drugs
- Accession number :
- edsair.pmid.dedup....7ffb6d08b99bba5a457b8a376330588d
- Full Text :
- https://doi.org/10.3390/md19090520⟩