Cohort Profile: The Ecuador Life (ECUAVIDA) study in Esmeraldas Province, Ecuador

Submitted by Maria Creuza Silva (mariakreuza@yahoo.com.br) on 2015-06-11T17:27:14Z No. of bitstreams: 1 Mauricio Lima. 2014.pdf: 1013895 bytes, checksum: 049178f11b0a0acea7bc1bf41a3008c7 (MD5) Made available in DSpace on 2015-06-11T17:27:14Z (GMT). No. of bitstreams: 1 Mauricio Lima. 2014.pdf: 1013895 bytes, checksum: 049178f11b0a0acea7bc1bf41a3008c7 (MD5) Previous issue date: 2014-07 The ECUAVIDA birth cohort is studying the impact of exposures to soil-transmitted helminth (STH) parasites and early-life microbial exposures on the development of atopy, allergic diseases and immune responses in childhood. A total of 2404 newborns were recruited between 2006 and 2009 in a public hospital serving the rural district of Quininde, Esmeraldas Province, in a tropical region of coastal Ecuador. Detailed measurements were done around the time of the birth, at 7 and 13 months and at 2 and 3 years, and data collection is ongoing at 5 and 8 years. Data being collected include questionnaires for: sociodemographic, lifestyle, psychosocial (at 4-6 years only) and dietary (at 6-7 years only) factors; childhood morbidity and clinical outcomes; stool samples for parasites; blood samples for DNA, measurements of vaccine responses and other measures of immune function/inflammation; and anthropometrics. Allergen skin prick test reactivity is done from 2 years and measures of airway function and inflammation at 8 years. London