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Integrative and Comprehensive Pancancer Analysis of Regulator of Chromatin Condensation 1 (RCC1)
- Source :
- International Journal of Molecular Sciences, Vol 22, Iss 7374, p 7374 (2021), International Journal of Molecular Sciences, Volume 22, Issue 14
- Publication Year :
- 2021
- Publisher :
- MDPI AG, 2021.
-
Abstract
- Regulator of Chromatin Condensation 1 (RCC1) is the only known guanine nucleotide exchange factor that acts on the Ras-like G protein Ran and plays a key role in cell cycle regulation. Although there is growing evidence to support the relationship between RCC1 and cancer, detailed pancancer analyses have not yet been performed. In this genome database study, based on The Cancer Genome Atlas, Genotype-Tissue Expression and Gene Expression Omnibus databases, the potential role of RCC1 in 33 tumors’ entities was explored. The results show that RCC1 is highly expressed in most human malignant neoplasms in contrast to healthy tissues. RCC1 expression is closely related to the prognosis of a broad variety of tumor patients. Enrichment analysis showed that some tumor-related pathways such as “cell cycle” and “RNA transport” were involved in the functional mechanism of RCC1. In particular, the conducted analysis reveals the relation of RCC1 to multiple immune checkpoint genes and suggests that the regulation of RCC1 is closely related to tumor infiltration of cancer-associated fibroblasts and CD8+ T cells. Coherent data demonstrate the association of RCC1 with the tumor mutation burden and microsatellite instability in various tumors. These findings provide new insights into the role of RCC1 in oncogenesis and tumor immunology in various tumors and indicate its potential as marker for therapy prognosis and targeted treatment strategies.
- Subjects :
- tumor
Carcinogenesis
QH301-705.5
Cell Cycle Proteins
Kaplan-Meier Estimate
CD8-Positive T-Lymphocytes
Article
enrichment analysis
Cancer-Associated Fibroblasts
big data
Neoplasms
Databases, Genetic
Guanine Nucleotide Exchange Factors
Humans
Protein Interaction Maps
Phosphorylation
Biology (General)
QD1-999
immune infiltration
Cell Cycle
Nuclear Proteins
pancancer
DNA Methylation
Immune Checkpoint Proteins
Chromatin
Gene Expression Regulation, Neoplastic
RCC1
Chemistry
Gene Ontology
Microsatellite Instability
prognosis
Transcriptome
Subjects
Details
- Language :
- English
- ISSN :
- 16616596 and 14220067
- Volume :
- 22
- Issue :
- 7374
- Database :
- OpenAIRE
- Journal :
- International Journal of Molecular Sciences
- Accession number :
- edsair.pmid.dedup....87d3fa1f7919f8280ee55bb922bace57