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Caveolin-1, breast cancer and ionizing radiation
- Source :
- Scopus-Elsevier, Europe PubMed Central
- Publication Year :
- 2015
-
Abstract
- Breast cancer (BC) recovery has increased in recent years thanks to efforts of Omics-based research in this field. However, despite the important results obtained, BC remains a complex multifactorial pathology that is difficult to treat appropriately. Caveolin-1 (CAV1), the basic constituent protein of specialized plasma membrane invaginations called caveolae, is emerging as a potential therapeutic biomarker in BC. This factor may modulate BC response to chemotherapy and radiation therapy. In addition, recent reports describe the key role of CAV1 during cell response to oxidative stress. The aim of the present review was to describe the biological roles of CAV1 in BC considering its contrasting dual functions as an oncogene and as a tumor suppressor. In addition, we report on how CAV1 may contribute to tumor cell response to ionizing radiation treatment. Finally, new roles of CAV1 in BC both on epithelium and stroma may be useful as prognostic indicators for patient treatment and help clinicians in the selection of the best personalized therapy.
- Subjects :
- Radiotherapy
Animal
CAV1
biomarker
breast cancer
ionizing radiation
review
Animals
Biomarkers, Tumor
Breast Neoplasms
Caveolin 1
Cell Transformation, Neoplastic
Female
Gene Expression Regulation, Neoplastic
Humans
Molecular Targeted Therapy
Receptor, Epidermal Growth Factor
Radiation, Ionizing
ErbB Receptors
Breast Neoplasm
Human
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Scopus-Elsevier, Europe PubMed Central
- Accession number :
- edsair.pmid.dedup....8a35a0fbf95e61e0f928cc5383797e5f