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Pharmacokinetics of mycophenolate mofetil in children with lupus and clinical findings in favour of therapeutic drug monitoring
- Source :
- British Journal of Clinical Pharmacology, British Journal of Clinical Pharmacology, Wiley, 2014, 78 ((4)), pp.867-76. ⟨10.1111/bcp.12392⟩, British Journal of Clinical Pharmacology, 2014, 78 ((4)), pp.867-76. ⟨10.1111/bcp.12392⟩, British Journal of Clinical Pharmacology, Wiley, 2014, 78 ((4)), pp.867-76. 〈10.1111/bcp.12392〉
- Publication Year :
- 2014
- Publisher :
- HAL CCSD, 2014.
-
Abstract
- International audience; AIMS: The use of mycophenolate mofetil (MMF) in children with Systemic Lupus Erythematosus (SLE) is increasing. However, the clinical benefit of its monitoring has been scarcely studied, and little is known about its pharmacokinetics in this context. The objectives of the present study were: (i) to describe mycophenolic acid (MPA; the active moiety of MMF) pharmacokinetics; (ii) to develop a Bayesian estimator (BE) allowing the determination AUC (Area under the curve) from a limited number of blood samples; and (ii) to explore the relationships between exposure indices to MPA and the clinical status in children with SLE. METHODS: This was a retrospective study including 36 children with SLE, extracted from the expert system ISBA, for whom full- pharmacokinetic profiles of MPA were collected together with clinical data. A pharmacokinetic model and a BE were developed using an iterative two-stage Bayesian approach. ROC curve analyses and logistic regressions was used to investigate the association of exposure and active disease. RESULTS: A pharmacokinetic model and a BE were developed that allowed good AUC estimation performance (bias±SD=-0.02±0.15). ROC curve analyses showed that AUC/dose
- Subjects :
- Male
Adolescent
Pharmacokinetic Dynamic Relationships
PK/PD
Bayes Theorem
[SDV.SP]Life Sciences [q-bio]/Pharmaceutical sciences
Systemic Lupus Erythematosus
[SDV.SP] Life Sciences [q-bio]/Pharmaceutical sciences
[ SDV.SP ] Life Sciences [q-bio]/Pharmaceutical sciences
Logistic Models
Area Under Curve
Child, Preschool
Humans
Lupus Erythematosus, Systemic
Female
Pharmacokinetics
Mycophenolic acid
Drug Monitoring
Child
Immunosuppressive Agents
Retrospective Studies
Subjects
Details
- Language :
- English
- ISSN :
- 03065251 and 13652125
- Database :
- OpenAIRE
- Journal :
- British Journal of Clinical Pharmacology, British Journal of Clinical Pharmacology, Wiley, 2014, 78 ((4)), pp.867-76. ⟨10.1111/bcp.12392⟩, British Journal of Clinical Pharmacology, 2014, 78 ((4)), pp.867-76. ⟨10.1111/bcp.12392⟩, British Journal of Clinical Pharmacology, Wiley, 2014, 78 ((4)), pp.867-76. 〈10.1111/bcp.12392〉
- Accession number :
- edsair.pmid.dedup....9016b18f7fe3ae29d74c6dc1be19bf34