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Multiparametric quantitative MRI assessment of thigh muscles in limb-girdle muscular dystrophy 2A and 2B
- Source :
- Muscle & Nerve, 58(4), 550. John Wiley and Sons Inc.
- Publication Year :
- 2018
- Publisher :
- John Wiley and Sons Inc., 2018.
-
Abstract
- Introduction: The aim of this study was to apply quantitative MRI (qMRI) to assess structural modifications in thigh muscles of subjects with limb girdle muscular dystrophy (LGMD) 2A and 2B with long disease duration. Methods: Eleven LGMD2A, 9 LGMD2B patients and 11 healthy controls underwent a multi-parametric 3T MRI examination of the thigh. The protocol included structural T1-weighted images, DIXON sequences for fat fraction calculation, T2 values quantification and diffusion MRI. Region of interest analysis was performed on 4 different compartments (anterior compartment, posterior compartment, gracilis, sartorius). Results: Patients showed high levels of fat infiltration as measured by DIXON sequences. Sartorius and anterior compartment were more infiltrated in LGMD2B than LGMD2A patients. T2 values were mildly reduced in both disorders. Correlations between clinical scores and qMRI were found. Conclusions: qMRI measures may help to quantify muscular degeneration, but careful interpretation is needed when fat infiltration is massive. Muscle Nerve 58: 550–558, 2018.
- Subjects :
- Adult
Male
Physiology
Clinical Neurology
Hamstring Muscles
Quadriceps Muscle
diffusion MRI
Young Adult
Cellular and Molecular Neuroscience
Physiology (medical)
Image Processing, Computer-Assisted
Humans
Mobility Limitation
Muscle, Skeletal
fat fraction
LGMD2A
LGMD2B
qMRI
T2 quantification
Neurology (clinical)
Middle Aged
Magnetic Resonance Imaging
Adipose Tissue
Muscular Dystrophies, Limb-Girdle
Thigh
Case-Control Studies
Female
Subjects
Details
- Language :
- English
- ISSN :
- 0148639X
- Database :
- OpenAIRE
- Journal :
- Muscle & Nerve, 58(4), 550. John Wiley and Sons Inc.
- Accession number :
- edsair.pmid.dedup....9867d201ff0d5ea14136d61c84319501