Back to Search
Start Over
The global distribution and diversity of protein vaccine candidate antigens in the highly virulent Streptococcus pnuemoniae serotype 1
- Source :
- Cornick, J E, Tastan Bishop, Ö, Yalcin, F, Kiran, A M, Kumwenda, B, Chaguza, C, Govindpershad, S, Ousmane, S, Senghore, M, du Plessis, M, Pluschke, G, Ebruke, C, McGee, L, Sigaùque, B, Collard, J-M, Bentley, S D, Kadioglu, A, Antonio, M, von Gottberg, A, French, N, Klugman, K P, Heyderman, R S & Alderson, M & Everett, D B 2017, ' The global distribution and diversity of protein vaccine candidate antigens in the highly virulent Streptococcus pnuemoniae serotype 1 ', Vaccine, vol. 35, no. 6, pp. 972-980 . https://doi.org/10.1016/j.vaccine.2016.12.037, Vaccine, Vaccine, Elsevier, 2017, 35 (6), pp.972-980. ⟨10.1016/j.vaccine.2016.12.037⟩, VACCINE
- Publication Year :
- 2017
-
Abstract
- International audience; Serotype 1 is one of the most common causes of pneumococcal disease worldwide. Pneumococcal protein vaccines are currently being developed as an alternate intervention strategy to pneumococcal conjugate vaccines. Pre-requisites for an efficacious pneumococcal protein vaccine are universal presence and minimal variation of the target antigen in the pneumococcal population, and the capability to induce a robust human immune response. We used in silico analysis to assess the prevalence of seven protein vaccine candidates (CbpA, PcpA, PhtD, PspA, SP0148, SP1912, SP2108) among 445 serotype 1 pneumococci from 26 different countries, across four continents. CbpA (76%), PspA (68%), PhtD (28%), PcpA (11%) were not universally encoded in the study population, and would not provide full coverage against serotype 1. PcpA was widely present in the European (82%), but not in the African (2%) population. A multi-valent vaccine incorporating CbpA, PcpA, PhtD and PspA was predicted to provide coverage against 86% of the global population. SP0148, SP1912 and SP2108 were universally encoded and we further assessed their predicted amino acid, antigenic and structural variation. Multiple allelic variants of these proteins were identified, different allelic variants dominated in different continents; the observed variation was predicted to impact the antigenicity and structure of two SP0148 variants, one SP1912 variant and four SP2108 variants, however these variants were each only present in a small fraction of the global population (
- Subjects :
- Models, Molecular
Vaccination Coverage
Antigenic diversity
MESH: Geography
MESH: Vaccines, Subunit
MESH: Amino Acid Sequence
MESH: Global Health
MESH: Africa
MESH: Virulence
Global Health
Structural diversity
Pneumococcal Vaccines
[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases
MESH: Pneumococcal Infections
Variant
MESH: Bacterial Proteins
Geography
Virulence
MESH: Asia
Research Support, Non-U.S. Gov't
MESH: Vaccination Coverage
Protein modelling
Antigenic Variation
Europe
Infectious Diseases
Streptococcus pneumoniae
Vaccines, Subunit
Molecular Medicine
MESH: Antigenic Variation
PCV
MESH: Models, Molecular
MESH: Streptococcus pneumoniae
MESH: Pneumococcal Vaccines
Asia
Antigenic profiling
Pneumococcal disease
Serogroup
Article
Pneumococcal Infections
Bacterial Proteins
Research Support, N.I.H., Extramural
Immunology and Microbiology(all)
Journal Article
Humans
Multi-valent
Amino Acid Sequence
Alleles
Antigens, Bacterial
MESH: Humans
MESH: Alleles
Public Health, Environmental and Occupational Health
MESH: Serogroup
MESH: South America
South America
veterinary(all)
[SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology
Africa
[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie
MESH: Europe
MESH: Antigens, Bacterial
Subjects
Details
- Language :
- English
- ISSN :
- 0264410X
- Database :
- OpenAIRE
- Journal :
- Cornick, J E, Tastan Bishop, Ö, Yalcin, F, Kiran, A M, Kumwenda, B, Chaguza, C, Govindpershad, S, Ousmane, S, Senghore, M, du Plessis, M, Pluschke, G, Ebruke, C, McGee, L, Sigaùque, B, Collard, J-M, Bentley, S D, Kadioglu, A, Antonio, M, von Gottberg, A, French, N, Klugman, K P, Heyderman, R S & Alderson, M & Everett, D B 2017, ' The global distribution and diversity of protein vaccine candidate antigens in the highly virulent Streptococcus pnuemoniae serotype 1 ', Vaccine, vol. 35, no. 6, pp. 972-980 . https://doi.org/10.1016/j.vaccine.2016.12.037, Vaccine, Vaccine, Elsevier, 2017, 35 (6), pp.972-980. ⟨10.1016/j.vaccine.2016.12.037⟩, VACCINE
- Accession number :
- edsair.pmid.dedup....9a7dc07e15ada02b78d45905a99fd88e