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Subsequent Event Risk in Individuals With Established Coronary Heart Disease Design and Rationale of the GENIUS-CHD Consortium
- Source :
- Circulation: Genomic and Precision Medicine, 12(4). LIPPINCOTT WILLIAMS & WILKINS, Circulation. Genomic and precision medicine, 12(4):002470. LIPPINCOTT WILLIAMS & WILKINS, Patel, R, Tragante, V, Schmidt, A F, McCubrey, R O, Holmes, M V, Howe, L J, Direk, K, Åkerblom, A, Leander, K, Virani, S S, Kaminski, K A, Muehlschlegel, J D, Allayee, H, Almgren, P, Alver, M, Baranova, E V, Behlouli, H, Boeckx, B, Braund, P S, Breitling, L P, Delgado, G, Duarte, N E, Dubé, M-P, Dufresne, L, Eriksson, N, Foco, L, Scholz, M, Gijsberts, C M, Glinge, C, Gong, Y, Hartiala, J, Heydarpour, M, Hubacek, J A, Kleber, M, Kofink, D, Kotti, S, Kuukasjärvi, P, Lee, V-V, Leiherer, A, Lenzini, P A, Levin, D, Lyytikäinen, L-P, Martinelli, N, Mons, U, Nelson, C P, Nikus, K, Pilbrow, A P, Ploski, R, Sun, Y V, Tanck, M W T, Tang, W H W, Trompet, S, van der Laan, S W, Van Setten, J, Vilmundarson, R O, Viviani Anselmi, C, Vlachopoulou, E, Al Ali, L, Boerwinkle, E, Briguori, C, Carlquist, J F, Carruthers, K F, Casu, G, Deanfield, J, Deloukas, P, Dudbridge, F, Engström, T, Fitzpatrick, N, Fox, K, Gigante, B, James, S, Lokki, M-L, Lotufo, P A, Marziliano, N, Mordi, I R, Muhlestein, J B, Newton-Cheh, C, Pitha, J, Saely, C H, Samman-Tahhan, A, Sandesara, P B, Teren, A, Timmis, A, Van de Werf, F, Wauters, E, Wilde, A A M, Ford, I, Stott, D J, Algra, A, Andreassi, M G, Ardissino, D, Arsenault, B J, Ballantyne, C M, Bergmeijer, T O, Bezzina, C R, Body, S C, Boersma, E H, Bogaty, P, Bots, M, Brenner, H, Brugts, J J, Burkhardt, R, Carpeggiani, C, Condorelli, G, Cooper-DeHoff, R M, Cresci, S, Danchin, N, de Faire, U, Doughty, R N, Drexel, H, Engert, J C, Fox, K A A, Girelli, D, Grobbee, D E, Hagström, E, Hazen, S L, Held, C, Hemingway, H, Hoefer, I E, Hovingh, G K, Jabbari, R, Johnson, J A, Jukema, J W, Kaczor, M P, Kähönen, M, Kettner, J, Kiliszek, M, Klungel, O H, Lagerqvist, B, Lambrechts, D, Laurikka, J O, Lehtimäki, T, Lindholm, D, Mahmoodi, B K, Maitland-van der Zee, A H, McPherson, R, Melander, O, Metspalu, A, Niemcunowicz-Janica, A, Olivieri, O, Opolski, G, Palmer, C N, Pasterkamp, G, Pepine, C J, Pereira, A C, Pilote, L, Quyyumi, A A, Richards, A M, Sanak, M, Siegbahn, A, Simon, T, Sinisalo, J, Smith, J G, Spertus, J A, Stender, S, Stewart, A F R, Szczeklik, W, Szpakowicz, A, Tardif, J-C, Ten Berg, J M, Tfelt-Hansen, J, Thanassoulis, G, Thiery, J, Torp-Pedersen, C, van der Graaf, Y, Visseren, F L J, Waltenberger, J, Weeke, P E, Van der Harst, P, Lang, C C, Sattar, N, Cameron, V A, Anderson, J L, Brophy, J M, Paré, G, Horne, B D, März, W, Wallentin, L, Samani, N J, Hingorani, A D & Asselbergs, F W 2019, ' Subsequent Event Risk in Individuals with Established Coronary Heart Disease : Design and Rationale of the GENIUS-CHD Consortium ', Circulation. Genomic and precision medicine, vol. 12, no. 4, e002470, pp. 145-160 . https://doi.org/10.1161/CIRCGEN.119.002470, Patel, R, Tragante, V, Schmidt, A F, McCubrey, R O, Holmes, M V, Howe, L J, Direk, K, Åkerblom, A, Leander, K, Virani, S S, Kaminski, K A, Muehlschlegel, J D, Allayee, H, Almgren, P, Alver, M, Baranova, E V, Behlouli, H, Boeckx, B, Braund, P S, Breitling, L P, Delgado, G, Duarte, N E, Dubé, M-P, Dufresne, L, Eriksson, N, Foco, L, Scholz, M, Gijsberts, C M, Glinge, C, Gong, Y, Hartiala, J, Heydarpour, M, Hubacek, J A, Kleber, M, Kofink, D, Kotti, S, Kuukasjärvi, P, Lee, V-V, Leiherer, A, Lenzini, P A, Levin, D, Lyytikäinen, L-P, Martinelli, N, Mons, U, Nelson, C P, Nikus, K, Pilbrow, A P, Ploski, R, Sun, Y V, Tanck, M W T, Tang, W H W, Trompet, S, van der Laan, S W, Van Setten, J, Vilmundarson, R O, Viviani Anselmi, C, Vlachopoulou, E, Al Ali, L, Boerwinkle, E, Briguori, C, Carlquist, J F, Carruthers, K F, Casu, G, Deanfield, J, Deloukas, P, Dudbridge, F, Engström, T, Fitzpatrick, N, Fox, K, Gigante, B, James, S, Lokki, M-L, Lotufo, P A, Marziliano, N, Mordi, I R, Muhlestein, J B, Newton-Cheh, C, Pitha, J, Saely, C H, Samman-Tahhan, A, Sandesara, P B, Teren, A, Timmis, A, Van de Werf, F, Wauters, E, Wilde, A A M, Ford, I, Stott, D J, Algra, A, Andreassi, M G, Ardissino, D, Arsenault, B J, Ballantyne, C M, Bergmeijer, T O, Bezzina, C R, Body, S C, Boersma, E H, Bogaty, P, Bots, M, Brenner, H, Brugts, J J, Burkhardt, R, Carpeggiani, C, Condorelli, G, Cooper-DeHoff, R M, Cresci, S, Danchin, N, de Faire, U, Doughty, R N, Drexel, H, Engert, J C, Fox, K A A, Girelli, D, Grobbee, D E, Hagström, E, Hazen, S L, Held, C, Hemingway, H, Hoefer, I E, Hovingh, G K, Jabbari, R, Johnson, J A, Jukema, J W, Kaczor, M P, Kähönen, M, Kettner, J, Kiliszek, M, Klungel, O H, Lagerqvist, B, Lambrechts, D, Laurikka, J O, Lehtimäki, T, Lindholm, D, Mahmoodi, B K, Maitland-van der Zee, A H, McPherson, R, Melander, O, Metspalu, A, Niemcunowicz-Janica, A, Olivieri, O, Opolski, G, Palmer, C N, Pasterkamp, G, Pepine, C J, Pereira, A C, Pilote, L, Quyyumi, A A, Richards, A M, Sanak, M, Siegbahn, A, Simon, T, Sinisalo, J, Smith, J G, Spertus, J A, Stender, S, Stewart, A F R, Szczeklik, W, Szpakowicz, A, Tardif, J-C, Ten Berg, J M, Tfelt-Hansen, J, Thanassoulis, G, Thiery, J, Torp-Pedersen, C, van der Graaf, Y, Visseren, F L J, Waltenberger, J, Weeke, P E, Van der Harst, P, Lang, C C, Sattar, N, Cameron, V A, Anderson, J L, Brophy, J M, Paré, G, Horne, B D, März, W, Wallentin, L, Samani, N J, Hingorani, A D & Asselbergs, F W 2019, ' Subsequent Event Risk in Individuals with Established Coronary Heart Disease : Design and Rationale of the GENIUS-CHD Consortium ', CIRCULATION-GENOMIC AND PRECISION MEDICINE, vol. 12, no. 4, pp. 145-160 . https://doi.org/10.1161/CIRCGEN.119.002470, Circulation. Genomic and precision medicine, 12(4). Lippincott Williams and Wilkins Ltd.
- Publication Year :
- 2019
- Publisher :
- LIPPINCOTT WILLIAMS & WILKINS, 2019.
-
Abstract
- BACKGROUND: The Genetics of Subsequent Coronary Heart Disease (GENIUS-CHD) consortium was established to facilitate discovery and validation of genetic variants and biomarkers for risk of subsequent CHD events, in individuals with established CHD. METHODS: The consortium currently includes 57 studies from 18 countries, recruiting 185 614 participants with either acute coronary syndrome, stable CHD, or a mixture of both at baseline. All studies collected biological samples and followed-up study participants prospectively for subsequent events. RESULTS: Enrollment into the individual studies took place between 1985 to present day with a duration of follow-up ranging from 9 months to 15 years. Within each study, participants with CHD are predominantly of self-reported European descent (38%-100%), mostly male (44%-91%) with mean ages at recruitment ranging from 40 to 75 years. Initial feasibility analyses, using a federated analysis approach, yielded expected associations between age (hazard ratio, 1.15; 95% CI, 1.14-1.16) per 5-year increase, male sex (hazard ratio, 1.17; 95% CI, 1.13-1.21) and smoking (hazard ratio, 1.43; 95% CI, 1.35-1.51) with risk of subsequent CHD death or myocardial infarction and differing associations with other individual and composite cardiovascular endpoints. CONCLUSIONS: GENIUS-CHD is a global collaboration seeking to elucidate genetic and nongenetic determinants of subsequent event risk in individuals with established CHD, to improve residual risk prediction and identify novel drug targets for secondary prevention. Initial analyses demonstrate the feasibility and reliability of a federated analysis approach. The consortium now plans to initiate and test novel hypotheses as well as supporting replication and validation analyses for other investigators. ispartof: CIRCULATION-GENOMIC AND PRECISION MEDICINE vol:12 issue:4 ispartof: location:United States status: published
- Subjects :
- Adult
Male
Cardiac & Cardiovascular Systems
CARDIOVASCULAR MORTALITY
Coronary Disease
BIOBANK
Article
Sex Factors
Risk Factors
Journal Article
Humans
ARTERY-DISEASE
Cardiac and Cardiovascular Systems
genetics
Aged
Proportional Hazards Models
Genetics & Heredity
Kardiologi
Science & Technology
Smoking
Age Factors
Middle Aged
BODY-MASS INDEX
myocardial infarction
MYOCARDIAL-INFARCTION
PUBLIC-HEALTH
Cardiovascular System & Cardiology
Female
prognosis
Life Sciences & Biomedicine
coronary artery disease
secondary prevention
Subjects
Details
- Language :
- English
- ISSN :
- 25748300
- Database :
- OpenAIRE
- Journal :
- Circulation: Genomic and Precision Medicine, 12(4). LIPPINCOTT WILLIAMS & WILKINS, Circulation. Genomic and precision medicine, 12(4):002470. LIPPINCOTT WILLIAMS & WILKINS, Patel, R, Tragante, V, Schmidt, A F, McCubrey, R O, Holmes, M V, Howe, L J, Direk, K, Åkerblom, A, Leander, K, Virani, S S, Kaminski, K A, Muehlschlegel, J D, Allayee, H, Almgren, P, Alver, M, Baranova, E V, Behlouli, H, Boeckx, B, Braund, P S, Breitling, L P, Delgado, G, Duarte, N E, Dubé, M-P, Dufresne, L, Eriksson, N, Foco, L, Scholz, M, Gijsberts, C M, Glinge, C, Gong, Y, Hartiala, J, Heydarpour, M, Hubacek, J A, Kleber, M, Kofink, D, Kotti, S, Kuukasjärvi, P, Lee, V-V, Leiherer, A, Lenzini, P A, Levin, D, Lyytikäinen, L-P, Martinelli, N, Mons, U, Nelson, C P, Nikus, K, Pilbrow, A P, Ploski, R, Sun, Y V, Tanck, M W T, Tang, W H W, Trompet, S, van der Laan, S W, Van Setten, J, Vilmundarson, R O, Viviani Anselmi, C, Vlachopoulou, E, Al Ali, L, Boerwinkle, E, Briguori, C, Carlquist, J F, Carruthers, K F, Casu, G, Deanfield, J, Deloukas, P, Dudbridge, F, Engström, T, Fitzpatrick, N, Fox, K, Gigante, B, James, S, Lokki, M-L, Lotufo, P A, Marziliano, N, Mordi, I R, Muhlestein, J B, Newton-Cheh, C, Pitha, J, Saely, C H, Samman-Tahhan, A, Sandesara, P B, Teren, A, Timmis, A, Van de Werf, F, Wauters, E, Wilde, A A M, Ford, I, Stott, D J, Algra, A, Andreassi, M G, Ardissino, D, Arsenault, B J, Ballantyne, C M, Bergmeijer, T O, Bezzina, C R, Body, S C, Boersma, E H, Bogaty, P, Bots, M, Brenner, H, Brugts, J J, Burkhardt, R, Carpeggiani, C, Condorelli, G, Cooper-DeHoff, R M, Cresci, S, Danchin, N, de Faire, U, Doughty, R N, Drexel, H, Engert, J C, Fox, K A A, Girelli, D, Grobbee, D E, Hagström, E, Hazen, S L, Held, C, Hemingway, H, Hoefer, I E, Hovingh, G K, Jabbari, R, Johnson, J A, Jukema, J W, Kaczor, M P, Kähönen, M, Kettner, J, Kiliszek, M, Klungel, O H, Lagerqvist, B, Lambrechts, D, Laurikka, J O, Lehtimäki, T, Lindholm, D, Mahmoodi, B K, Maitland-van der Zee, A H, McPherson, R, Melander, O, Metspalu, A, Niemcunowicz-Janica, A, Olivieri, O, Opolski, G, Palmer, C N, Pasterkamp, G, Pepine, C J, Pereira, A C, Pilote, L, Quyyumi, A A, Richards, A M, Sanak, M, Siegbahn, A, Simon, T, Sinisalo, J, Smith, J G, Spertus, J A, Stender, S, Stewart, A F R, Szczeklik, W, Szpakowicz, A, Tardif, J-C, Ten Berg, J M, Tfelt-Hansen, J, Thanassoulis, G, Thiery, J, Torp-Pedersen, C, van der Graaf, Y, Visseren, F L J, Waltenberger, J, Weeke, P E, Van der Harst, P, Lang, C C, Sattar, N, Cameron, V A, Anderson, J L, Brophy, J M, Paré, G, Horne, B D, März, W, Wallentin, L, Samani, N J, Hingorani, A D & Asselbergs, F W 2019, ' Subsequent Event Risk in Individuals with Established Coronary Heart Disease : Design and Rationale of the GENIUS-CHD Consortium ', Circulation. Genomic and precision medicine, vol. 12, no. 4, e002470, pp. 145-160 . https://doi.org/10.1161/CIRCGEN.119.002470, Patel, R, Tragante, V, Schmidt, A F, McCubrey, R O, Holmes, M V, Howe, L J, Direk, K, Åkerblom, A, Leander, K, Virani, S S, Kaminski, K A, Muehlschlegel, J D, Allayee, H, Almgren, P, Alver, M, Baranova, E V, Behlouli, H, Boeckx, B, Braund, P S, Breitling, L P, Delgado, G, Duarte, N E, Dubé, M-P, Dufresne, L, Eriksson, N, Foco, L, Scholz, M, Gijsberts, C M, Glinge, C, Gong, Y, Hartiala, J, Heydarpour, M, Hubacek, J A, Kleber, M, Kofink, D, Kotti, S, Kuukasjärvi, P, Lee, V-V, Leiherer, A, Lenzini, P A, Levin, D, Lyytikäinen, L-P, Martinelli, N, Mons, U, Nelson, C P, Nikus, K, Pilbrow, A P, Ploski, R, Sun, Y V, Tanck, M W T, Tang, W H W, Trompet, S, van der Laan, S W, Van Setten, J, Vilmundarson, R O, Viviani Anselmi, C, Vlachopoulou, E, Al Ali, L, Boerwinkle, E, Briguori, C, Carlquist, J F, Carruthers, K F, Casu, G, Deanfield, J, Deloukas, P, Dudbridge, F, Engström, T, Fitzpatrick, N, Fox, K, Gigante, B, James, S, Lokki, M-L, Lotufo, P A, Marziliano, N, Mordi, I R, Muhlestein, J B, Newton-Cheh, C, Pitha, J, Saely, C H, Samman-Tahhan, A, Sandesara, P B, Teren, A, Timmis, A, Van de Werf, F, Wauters, E, Wilde, A A M, Ford, I, Stott, D J, Algra, A, Andreassi, M G, Ardissino, D, Arsenault, B J, Ballantyne, C M, Bergmeijer, T O, Bezzina, C R, Body, S C, Boersma, E H, Bogaty, P, Bots, M, Brenner, H, Brugts, J J, Burkhardt, R, Carpeggiani, C, Condorelli, G, Cooper-DeHoff, R M, Cresci, S, Danchin, N, de Faire, U, Doughty, R N, Drexel, H, Engert, J C, Fox, K A A, Girelli, D, Grobbee, D E, Hagström, E, Hazen, S L, Held, C, Hemingway, H, Hoefer, I E, Hovingh, G K, Jabbari, R, Johnson, J A, Jukema, J W, Kaczor, M P, Kähönen, M, Kettner, J, Kiliszek, M, Klungel, O H, Lagerqvist, B, Lambrechts, D, Laurikka, J O, Lehtimäki, T, Lindholm, D, Mahmoodi, B K, Maitland-van der Zee, A H, McPherson, R, Melander, O, Metspalu, A, Niemcunowicz-Janica, A, Olivieri, O, Opolski, G, Palmer, C N, Pasterkamp, G, Pepine, C J, Pereira, A C, Pilote, L, Quyyumi, A A, Richards, A M, Sanak, M, Siegbahn, A, Simon, T, Sinisalo, J, Smith, J G, Spertus, J A, Stender, S, Stewart, A F R, Szczeklik, W, Szpakowicz, A, Tardif, J-C, Ten Berg, J M, Tfelt-Hansen, J, Thanassoulis, G, Thiery, J, Torp-Pedersen, C, van der Graaf, Y, Visseren, F L J, Waltenberger, J, Weeke, P E, Van der Harst, P, Lang, C C, Sattar, N, Cameron, V A, Anderson, J L, Brophy, J M, Paré, G, Horne, B D, März, W, Wallentin, L, Samani, N J, Hingorani, A D & Asselbergs, F W 2019, ' Subsequent Event Risk in Individuals with Established Coronary Heart Disease : Design and Rationale of the GENIUS-CHD Consortium ', CIRCULATION-GENOMIC AND PRECISION MEDICINE, vol. 12, no. 4, pp. 145-160 . https://doi.org/10.1161/CIRCGEN.119.002470, Circulation. Genomic and precision medicine, 12(4). Lippincott Williams and Wilkins Ltd.
- Accession number :
- edsair.pmid.dedup....9b2445bbb0c14f93c127d62c7bc86af0