Back to Search
Start Over
Recent Randomized Trials of Antithrombotic Therapy for Patients With COVID-19:JACC State-of-the-Art Review
- Source :
- Talasaz, A H, Sadeghipour, P, Kakavand, H, Aghakouchakzadeh, M, Kordzadeh-Kermani, E, Van Tassell, B W, Gheymati, A, Ariannejad, H, Hosseini, S H, Jamalkhani, S, Sholzberg, M, Monreal, M, Jimenez, D, Piazza, G, Parikh, S A, Kirtane, A J, Eikelboom, J W, Connors, J M, Hunt, B J, Konstantinides, S V, Cushman, M, Weitz, J I, Stone, G W, Krumholz, H M, Lip, G Y H, Goldhaber, S Z & Bikdeli, B 2021, ' Recent Randomized Trials of Antithrombotic Therapy for Patients With COVID-19 : JACC State-of-the-Art Review ', Journal of the American College of Cardiology, vol. 77, no. 15, pp. 1903-1921 . https://doi.org/10.1016/j.jacc.2021.02.035, Journal of the American College of Cardiology
- Publication Year :
- 2021
-
Abstract
- Endothelial injury and microvascular/macrovascular thrombosis are common pathophysiological features of coronavirus disease-2019 (COVID-19). However, the optimal thromboprophylactic regimens remain unknown across the spectrum of illness severity of COVID-19. A variety of antithrombotic agents, doses, and durations of therapy are being assessed in ongoing randomized controlled trials (RCTs) that focus on outpatients, hospitalized patients in medical wards, and patients critically ill with COVID-19. This paper provides a perspective of the ongoing or completed RCTs related to antithrombotic strategies used in COVID-19, the opportunities and challenges for the clinical trial enterprise, and areas of existing knowledge, as well as data gaps that may motivate the design of future RCTs.<br />Central Illustration
- Subjects :
- PaO2/FiO2, partial arterial pressure of oxygen/fraction of inspired oxygen
HMGB1, high-mobility group box protein 1
VTE, venous thromboembolism
antiplatelet
WHO, World Health Organization
Fibrinolytic Agents
NET, neutrophil extracellular trap
QD, once daily
Thromboembolism
BID, twice daily
Humans
CrCl, creatinine clearance
UFH, unfractionated heparin
RCT, randomized controlled trial
LMWH, low-molecular-weight heparin
thrombosis
Randomized Controlled Trials as Topic
DOAC, direct oral anticoagulant
COVID-19, coronavirus disease-2019
anticoagulant
SARS-CoV-2, severe acute respiratory syndrome-coronavirus-2
COVID-19
clinical trial
ICU, intensive care unit
COVID-19 Drug Treatment
JACC State-Of-The-Art Review
CI, confidence interval
RCT
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Talasaz, A H, Sadeghipour, P, Kakavand, H, Aghakouchakzadeh, M, Kordzadeh-Kermani, E, Van Tassell, B W, Gheymati, A, Ariannejad, H, Hosseini, S H, Jamalkhani, S, Sholzberg, M, Monreal, M, Jimenez, D, Piazza, G, Parikh, S A, Kirtane, A J, Eikelboom, J W, Connors, J M, Hunt, B J, Konstantinides, S V, Cushman, M, Weitz, J I, Stone, G W, Krumholz, H M, Lip, G Y H, Goldhaber, S Z & Bikdeli, B 2021, ' Recent Randomized Trials of Antithrombotic Therapy for Patients With COVID-19 : JACC State-of-the-Art Review ', Journal of the American College of Cardiology, vol. 77, no. 15, pp. 1903-1921 . https://doi.org/10.1016/j.jacc.2021.02.035, Journal of the American College of Cardiology
- Accession number :
- edsair.pmid.dedup....9cfd53875c4beb17c4b2acdd6680cbaf
- Full Text :
- https://doi.org/10.1016/j.jacc.2021.02.035