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Dynamic reciprocal relationships between cognitive and functional declines along the Alzheimer’s disease continuum in the prospective COGICARE study
- Source :
- Alzheimer's Research and Therapy, Alzheimer's Research and Therapy, BioMed Central, 2021, 13 (1), pp.148. ⟨10.1186/s13195-021-00887-4⟩, Alzheimer's Research and Therapy, 2021, 13 (1), pp.148. ⟨10.1186/s13195-021-00887-4⟩, Alzheimer's Research & Therapy, Alzheimer’s Research & Therapy, Vol 13, Iss 1, Pp 1-12 (2021)
- Publication Year :
- 2021
- Publisher :
- HAL CCSD, 2021.
-
Abstract
- Background Thoroughly understanding the temporal associations between cognitive and functional dimensions along the dementia process is fundamental to define preventive measures likely to delay the disease’s onset. This work aimed to finely describe the trajectories of cognitive and functional declines, and assess their dynamic bidirectional relationships among subjects at different stages of the dementia process. Methods We leveraged extensive repeated data of cognition and functional dependency from the French prospective COGICARE study, designed to better characterize the natural history of cognitive and functional declines around dementia diagnosis. Cognition was measured by the Mini-Mental State Examination, the Isaacs Set Test for verbal fluency, the Benton Visual Retention Test for visuo-spatial memory, and Trail Making Test Part B for executive functioning. Functional dependency was measured by basic and instrumental activities of daily living. The study included 102 cognitively normal, 123 mildly cognitively impaired, and 72 dementia cases with a median of 5 repeated visits over up to 57 months. We used a dynamic causal model which addresses the two essential issues in temporal associations assessment: focusing on intra-individual change and accounting for time. Results Better cognitive abilities were associated with lower subsequent decline of the functional level among the three clinical stages with an intensification over time but no reciprocity of the association whatever the clinical status. Conclusion This work confirms that the progressive functional dependency could be induced by cognitive impairment. Subjects identified as early as possible with clinically significant cognitive impairments could benefit from preventive measures before the deterioration of activities of daily living and the appearance of dementia clinical signs. Supplementary Information The online version contains supplementary material available at 10.1186/s13195-021-00887-4.
- Subjects :
- Neurosciences. Biological psychiatry. Neuropsychiatry
MESH: Cognition
Neuropsychological Tests
MESH: Cognitive Dysfunction
Cognitive aging
Cognition
[STAT.AP] Statistics [stat]/Applications [stat.AP]
Alzheimer Disease
Humans
Cognitive Dysfunction
Prospective Studies
RC346-429
[STAT.AP]Statistics [stat]/Applications [stat.AP]
MESH: Humans
Research
MESH: Activities of Daily Living
Activities of daily living
MESH: Neuropsychological Tests
MESH: Prospective Studies
Causality
Temporal association
[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie
Mini-Mental State Examination
Dementia
[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie
Neurology. Diseases of the nervous system
MESH: Alzheimer Disease
RC321-571
Subjects
Details
- Language :
- English
- ISSN :
- 17589193
- Database :
- OpenAIRE
- Journal :
- Alzheimer's Research and Therapy, Alzheimer's Research and Therapy, BioMed Central, 2021, 13 (1), pp.148. ⟨10.1186/s13195-021-00887-4⟩, Alzheimer's Research and Therapy, 2021, 13 (1), pp.148. ⟨10.1186/s13195-021-00887-4⟩, Alzheimer's Research & Therapy, Alzheimer’s Research & Therapy, Vol 13, Iss 1, Pp 1-12 (2021)
- Accession number :
- edsair.pmid.dedup....a5dc8ba71c1383c465a0de25a2ffdd00
- Full Text :
- https://doi.org/10.1186/s13195-021-00887-4⟩