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Long-term follow-up study in breast cancer patients using serum tumor markers CEA and CA 15-3
- Source :
- Scopus-Elsevier, Europe PubMed Central
-
Abstract
- The aim of this study was to evaluate CEA and CA 15-3 changes in patients surgically treated for breast cancer. One hundred and three women (median age 59 years, range 31-83 years) with pT1-2, pN0-1, M0 breast cancer were followed up for at least 5 years. CEA and CA 15-3 serum levels were measured before operation and every 6 months during follow-up. The diagnostic sensitivity of CEA and CA 15-3 was 22.3% and 33.3% respectively. There was a significant difference (p0.01) between pre- and post-operative (6 months and 5 years after surgery) mean CEA serum levels independent of TNM staging. During follow-up, 21 (20.4%) patients showed recurrence of cancer and overall CEA and CA 15-3 sensitivity was 38.1% and 61.1%, with 98.8% and 91.2% specificity, respectively. Tumor marker measurement may be useful in post-surgical follow-up, but at present they are neither sensitive nor specific enough for early diagnosis of malignancy.
- Subjects :
- Adult
Time Factors
Breast Neoplasms
Breast cancer
CEA
Predictive Value of Tests
HER2
Biomarkers, Tumor
cancer
Humans
CA 153
early breast cancer
breast
Aged
Aged, 80 and over
breast diseases
Mucin-1
prognostic factors
estrogen receptors
Middle Aged
Carcinoembryonic Antigen
tumor markers
Female
CA 15-3
Breast cancer, breast, cancer, early breast cancer, breast diseases, malignancy, tumor markers, CA 15-3, CA 153, CEA, estrogen receptors, HER2, prognostic factors
malignancy
Follow-Up Studies
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- Scopus-Elsevier, Europe PubMed Central
- Accession number :
- edsair.pmid.dedup....a7ad13ea0a896353ffcb23db9d143338