Back to Search
Start Over
Genetic structure of marine Borrelia garinii and population admixture with the terrestrial cycle of Lyme borreliosis
- Source :
- Environmental Microbiology, Environmental Microbiology, Wiley-Blackwell, 2011, 13 (9), pp.2453-67. ⟨10.1111/j.1462-2920.2011.02515.x⟩, Digital.CSIC. Repositorio Institucional del CSIC, instname, Environmental Microbiology, Society for Applied Microbiology and Wiley-Blackwell, 2011, 13 (9), pp.2453-67. ⟨10.1111/j.1462-2920.2011.02515.x⟩, Environmental Microbiology, 2011, 13 (9), pp.2453-67. ⟨10.1111/j.1462-2920.2011.02515.x⟩
- Publication Year :
- 2011
-
Abstract
- Despite the importance of population structure for the epidemiology of pathogenic bacteria, the spatial and ecological heterogeneity of these populations is often poorly characterized. Here, we investigated the genetic diversity and population structure of the Lyme borreliosis (LB) spirochaete Borrelia garinii in its marine cycle involving colonial seabirds and different host races of the seabird tick Ixodes uriae. Multilocus sequence analyses (MLSA) on eight chromosomal and two plasmid loci (ospA and ospC) indicate that B. garinii circulating in the marine system is highly diverse. Microevolution in marine B. garinii seems to be mainly clonal, but recombination and selection do occur. Sequence types were not evenly distributed among geographic regions, with substantial population subdivision between Atlantic and Pacific Ocean basins. However, no geographic structuring was evident within regions. Results of selection analyses and phylogenetic discordance between chromosomal and plasmid loci indicate adaptive evolution is likely occurring in this system, but no pattern of host or vector-associated divergence was found. Recombination analyses showed evidence for population admixture between terrestrial and marine strains, suggesting that LB spirochaetes are exchanged between these enzootic cycles. Importantly, our results highlight the need to explicitly consider the marine system for a complete understanding of the evolutionary ecology and global epidemiology of Lyme borreliosis.<br />Este trabajo ha sido financiado por ‘Institut Polaire-Paul Emile Victor’ (IPEV, programme No. 333), Centre National de la Recherche Scientifique (CNRS – Emerging Infectious Disease Interdisciplinary Program) y la Agence National de la Recherche (ANR-06-JCJC-0095-01). Además también ha recibido financiacion a través de la beca Marie Curie No. PIEF-GA-2008-221243 obtenida por E.Gómez-Díaz.
- Subjects :
- DNA, Bacterial
MESH: Geography
MESH: Lyme Disease
MESH: Selection, Genetic
MESH: Genetics, Population
MESH: Base Sequence
MESH: Bacterial Typing Techniques
MESH: Ixodes
Birds
Evolution, Molecular
Borrelia burgdorferi Group
Animals
MESH: Animals
MESH: Borrelia burgdorferi Group
MESH: Genetic Variation
Selection, Genetic
MESH: Pacific Ocean
MESH: Phylogeny
Atlantic Ocean
Phylogeny
MESH: Evolution, Molecular
[SDV.MP.MYC]Life Sciences [q-bio]/Microbiology and Parasitology/Mycology
Recombination, Genetic
MESH: Atlantic Ocean
Lyme Disease
Pacific Ocean
Base Sequence
Geography
Ixodes
Genetic Variation
bacterial infections and mycoses
MESH: DNA, Bacterial
Bacterial Typing Techniques
Genetics, Population
MESH: Multilocus Sequence Typing
Genes, Bacterial
MESH: Birds
MESH: Recombination, Genetic
MESH: Genes, Bacterial
Multilocus Sequence Typing
Subjects
Details
- ISSN :
- 14622912 and 14622920
- Database :
- OpenAIRE
- Journal :
- Environmental Microbiology, Environmental Microbiology, Wiley-Blackwell, 2011, 13 (9), pp.2453-67. ⟨10.1111/j.1462-2920.2011.02515.x⟩, Digital.CSIC. Repositorio Institucional del CSIC, instname, Environmental Microbiology, Society for Applied Microbiology and Wiley-Blackwell, 2011, 13 (9), pp.2453-67. ⟨10.1111/j.1462-2920.2011.02515.x⟩, Environmental Microbiology, 2011, 13 (9), pp.2453-67. ⟨10.1111/j.1462-2920.2011.02515.x⟩
- Accession number :
- edsair.pmid.dedup....a87fe4b911e56448f57828ed1024ec2c