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Innovative non-animal testing strategies for reproductive toxicology: the contribution of Italian partners within the EU project ReProTect
- Source :
- Annali dell'Istituto Superiore di Sanità, Vol 47, Iss 4, Pp 429-444 (2011)
- Publication Year :
- 2011
- Publisher :
- Istituto Superiore di Sanità, 2011.
-
Abstract
- Reproductive toxicity, with its many targets and mechanisms, is a complex area of toxicology; thus, the screening and identification of reproductive toxicants is a main scientific challenge for the safety assessment of chemicals, including the European Regulation on Chemicals (REACH). Regulatory agencies recommend the implementation of the 3Rs principle (refinement, reduction, replacement) as well as of intelligent testing strategies, through the development of in vitro methods and the use of mechanistic information in the hazard identification and characterization steps of the risk assessment process. The EU Integrated Project ReProTect (6th Framework Programme) implemented an array of in vitro tests to study different building blocks of the mammalian reproductive cycle: methodological developments and results on male and female germ cells, prostate and placenta are presented.
- Subjects :
- Adult
Male
metodi alternativi
placenta
Drug Evaluation, Preclinical
ReProTect
Animal Testing Alternatives
Toxicology
reproductive toxicology
Pregnancy
Animals
Humans
European Union
cellule germinali maschili e femminili
Mutagenicity Tests
Reproduction
lcsh:Public aspects of medicine
prostata
Prostate
lcsh:RA1-1270
Spermatozoa
Germ Cells
Italy
Research Design
Fertilization
Oocytes
REACH
Cattle
Female
Mutagens
Subjects
Details
- Language :
- English
- ISSN :
- 00212571
- Volume :
- 47
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Annali dell'Istituto Superiore di Sanità
- Accession number :
- edsair.pmid.dedup....c0c1e3296538f262eb5dd8e9a0e6958f