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131I-meta-iodobenzylguanidine scintigraphy in patients with a suspected pheochromocytoma. A comparison with CT and biohumoral parameters
- Publication Year :
- 1991
-
Abstract
- The results of 131I metaiodobenzylguanidine (MIBG) and Computed Tomography (CT) scans in a group of patients with clinically suspected pheochromocytoma were evaluated and compared with biohumoral parameters. We studied 24 consecutive patients (7 M and 17 F; age range 20-66 years). 131I-MIBG scintigraphy and CT were in agreement in 19 patients (79%): of them 7 cases were true positive, and 12 were true negative. Disagreement between the two imaging techniques was observed in 5 patients (21%). In this group, one patient, with positive CT scan, had false negative MIBG study, while 4 patients with negative MIBG scan, had false positive CT. MIBG showed significantly higher (p less than 0.05) specificity (100%), positive predictive value (100%), and accuracy (96%) than CT (75%, 67%, and 83%, respectively). 131I-MIBG scintigraphy is an accurate, noninvasive technique for localizing pheochromocytoma and providing direct tissue characterization, while CT provides more accurate spatial information. In conclusion, CT and MIBG studies are complementary in the evaluation of patients with suspected pheochromocytoma.
- Subjects :
- Adult
Male
3-Iodobenzylguanidine
Adrenal Gland Neoplasms
Adrenal Glands
Aged
Catecholamines
Evaluation Studies as Topic
Female
Humans
Middle Aged
Pheochromocytoma
Radionuclide Imaging
Sensitivity and Specificity
Contrast Media
Iodine Radioisotopes
Iodobenzenes
Tomography, X-Ray Computed
X-Ray Computed
Tomography
Subjects
Details
- Language :
- Italian
- Database :
- OpenAIRE
- Accession number :
- edsair.pmid.dedup....c329a5acd54716ac291cb6cab7e18e7d