油症認定患者におけるアトピー性皮膚炎有病率と血清IgE値に関する研究第2報

Dioxins may have an impact on the human immunological system, which would increase the risk to develop allergic diseases, such as atopic dermatitis. In order to determine the lifetime prevalence of atopic dermatitis in Yusho patients, a questionnaire-based survey was conducted in 2008. One thousand and seventy-one out of 1430 certified yusho patients who were born before Yusho accident answered the questionnaires, and the prevalence of atopic dermatitis in Yusho patients was 5.5%. We also measured serum IgE in 515 Yusho patients who attended annual medical check-ups from 2007 to 2009 and in 172 control subjects. Serum levels of IgE in Yusho patients were 250.7 ± 663.4 IU/ml, whereas those in control subjects were 265.0 ± 602.0 IU/ml. There was no significant difference in serum levels of IgE between Yusho patients and control subjects. In addition, no significant correlation was observed between serum levels of IgE and blood levels of dioxins in Yusho patients.
油症発生から40 年が経過し，発症早期に認められた典型的な皮膚科所見，眼科所見を有する患者は減少しているが，発癌性や次世代への影響など慢性毒性への懸念は依然強い．ダイオキシン類の慢性毒性の一つとして，免疫系への影響があげられ，近年のアレルギー性疾患の増加とダイオキシン類による環境汚染との関連が議論されることがある．本研究では，経口的に高濃度のダイオキシン類に暴露された油症患者における，アトピー性皮膚炎有病率および血清IgE 値について調査し，血中ダイオキシン類濃度との相関について検討した．