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Immediate and Midterm Cardiac Remodeling After Surgical Pulmonary Valve Replacement in Adults With Repaired Tetralogy of Fallot: A Prospective Cardiovascular Magnetic Resonance and Clinical Study

Authors :
Heng, Ee Ling
Gatzoulis, Michael A.
Uebing, Anselm
Sethia, Babulal
Uemura, Hideki
Smith, Gillian C.
Diller, Gerhard-Paul
McCarthy, Karen P.
Ho, Siew Yen
Li, Wei
Wright, Piers
Spadotto, Veronica
Kilner, Philip J
Oldershaw, Paul
Pennell, Dudley J.
Shore, Darryl F.
Babu-Narayan, Sonya V.
Source :
Circulation
Publication Year :
2017

Abstract

Supplemental Digital Content is available in the text.<br />Background: Pulmonary valve replacement (PVR) in patients with repaired tetralogy of Fallot provides symptomatic benefit and right ventricular (RV) volume reduction. However, data on the rate of ventricular structural and functional adaptation are scarce. We aimed to assess immediate and midterm post-PVR changes and predictors of reverse remoeling. Methods: Fifty-seven patients with repaired tetralogy of Fallot (age ≥16 y; mean age, 35.8±10.1 y; 38 male) undergoing PVR were prospectively recruited for cardiovascular magnetic resonance performed before PVR (pPVR), immediately after PVR (median, 6 d), and midterm after PVR (mPVR; median, 3 y). Results: There were immediate and midterm reductions in indexed RV end-diastolic volumes and RV end-systolic volumes (RVESVi) (indexed RV end-diastolic volume pPVR versus immediately after PVR versus mPVR, 156.1±41.9 versus 104.9±28.4 versus 104.2±34.4 mL/m2; RVESVi pPVR versus immediately after PVR versus mPVR, 74.9±26.2 versus 57.4±22.7 versus 50.5±21.7 mL/m2; P

Details

ISSN :
15244539
Volume :
136
Issue :
18
Database :
OpenAIRE
Journal :
Circulation
Accession number :
edsair.pmid.dedup....d4b99ae45f0a6549a60b6c621b7f15cc