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Brain abnormalities in schizophrenia. A qualitative comparative study of schizophrenic patients and control individuals assessed by magnetic resonance imaging
- Source :
- Journal of neuroradiology = Journal de neuroradiologie. 33(3)
- Publication Year :
- 2006
-
Abstract
- The present study examined, by means of Magnetic Resonance Imaging (MRI), the qualitative brain abnormalities in a group of 58 schizophrenic patients compared to a group of 58 matched control individuals. The possible relationships between these abnormalities and the demographic and clinical features of the participants in the study were also investigated. Schizophrenic patients presented a higher percentage of bland-moderate enlargement of the periencephalic-subarachnoid spaces (p=0.01) and a widespread cerebral atrophy, the latter below the threshold of significance (p=0.06). In the subset of patients with ventricular asymmetry (right larger than left) the age was significantly lower compared to the age of patients without this abnormality (p=0.04). In the subset of patients with cerebellar cisterns enlargement the age as well as the age of onset was higher in comparison to the one of patients without this abnormality (p=0.02; p=0.006). Taking together with previous studies, these findings underline the importance of qualitative assessment of brain morphology in research and clinical evaluation of patients with schizophrenia.
- Subjects :
- Adult
Male
Analysis of Variance
Chi-Square Distribution
Adolescent, Adult, Analysis of Variance, Case-Control Studies, Cerebral Ventricles
pathology, Chi-Square Distribution, Humans, Magnetic Resonance Imaging
methods, Male, Middle Aged, Schizophrenia
pathology
Adolescent
Middle Aged
Magnetic Resonance Imaging
methods
Cerebral Ventricles
Case-Control Studies
Schizophrenia
Humans
Subjects
Details
- ISSN :
- 01509861
- Volume :
- 33
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Journal of neuroradiology = Journal de neuroradiologie
- Accession number :
- edsair.pmid.dedup....e28f48047c305e9f07bc233daabf5f29