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Contrast-enhanced spectral mammography with a compact synchrotron source
- Source :
- PLoS ONE, PLoS ONE, Vol 14, Iss 10, p e0222816 (2019)
- Publication Year :
- 2019
- Publisher :
- Public Library of Science, 2019.
-
Abstract
- For early breast cancer detection, mammography is nowadays the commonly used standard imaging approach, offering a valuable clinical tool for visualization of suspicious findings like microcalcifications and tumors within the breast. However, due to the superposition of anatomical structures, the sensitivity of mammography screening is limited. Within the last couple of years, the implementation of contrast-enhanced spectral mammography (CESM) based on K-edge subtraction (KES) imaging helped to improve the identification and classification of uncertain findings. In this study, we introduce another approach for CESM based on a two-material decomposition, with which we expect fundamental improvements compared to the clinical procedure. We demonstrate the potential of our proposed method using the quasi-monochromatic radiation of a compact synchrotron source-the Munich Compact Light Source (MuCLS)-and a modified mammographic accreditation phantom. For direct comparison with the clinical CESM approach, we also performed a standard dual-energy KES at the MuCLS, which outperformed the clinical CESM images in terms of contrast-to-noise ratio (CNR) and spatial resolution. However, the dual-energy-based two-material decomposition approach achieved even higher CNR values. Our experimental results with quasi-monochromatic radiation show a significant improvement of the image quality at lower mean glandular dose (MGD) than the clinical CESM. At the same time, our study indicates the great potential for the material-decomposition instead of clinically used KES to improve the quantitative outcome of CESM.
- Subjects :
- Imaging Techniques
Science
Equipment
Contrast Media
Neuroimaging
Breast Neoplasms
Research and Analysis Methods
Diagnostic Radiology
Diagnostic Medicine
Medicine and Health Sciences
Humans
Breast
Particle Physics
Early Detection of Cancer
Photons
Phantoms, Imaging
Radiology and Imaging
Physics
Biology and Life Sciences
Calcinosis
Bone Imaging
Calcium Imaging
Clinical Laboratory Sciences
X-Ray Radiography
Radiographic Image Enhancement
Chemistry
Clinical Laboratories
Physical Sciences
Medicine
Engineering and Technology
Female
Particle Accelerators
Synchrotrons
Elementary Particles
Research Article
Chemical Elements
Iodine
Mammography
Neuroscience
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 14
- Issue :
- 10
- Database :
- OpenAIRE
- Journal :
- PLoS ONE
- Accession number :
- edsair.pmid.dedup....eeca5b1e3bf961419978ccb8da54d92b