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Update on Fc-Mediated Antibody Functions Against HIV-1 Beyond Neutralization

Authors :
Su, Bin
Dispinseri, Stefania
Iannone, Valeria
ZHANG, Tong
Wu, Hao
Carapito, Raphael
Bahram, Seiamak
Scarlatti, Gabriella
Moog, Christiane
Capital University of Medical Sciences [Beijing] (CUMS)
San Raffaele Scientific Institute
Vita-Salute San Raffaele University and Center for Translational Genomics and Bioinformatics
Immuno-Rhumatologie Moléculaire
Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)
LabEx Transplantex [Strasbourg]
Université de Strasbourg (UNISTRA)
Fédération Hospitalo-Universitaire (OMICARE)
Centre de Recherche d’Immunologie et d’Hématologie [Strasbourg]
Fédération de Médecine Translationnelle de Strasbourg (FMTS)
Vaccine Research Institute (VRI)
Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)
Source :
Frontiers in Immunology, Frontiers in Immunology, Frontiers, 2019, 10, ⟨10.3389/fimmu.2019.02968⟩
Publication Year :
2019
Publisher :
Frontiers Media S.A., 2019.

Abstract

Antibodies (Abs) are the major component of the humoral immune response and a key player in vaccination. The precise Ab-mediated inhibitory mechanisms leading to in vivo protection against HIV have not been elucidated. In addition to the desired viral capture and neutralizing Ab functions, complex Ab-dependent mechanisms that involve engaging immune effector cells to clear infected host cells, immune complexes, and opsonized virus have been proposed as being relevant. These inhibitory mechanisms involve Fc-mediated effector functions leading to Ab-dependent cellular cytotoxicity, phagocytosis, cell-mediated virus inhibition, aggregation, and complement inhibition. Indeed, the decreased risk of infection observed in the RV144 HIV-1 vaccine trial was correlated with the production of non-neutralizing inhibitory Abs, highlighting the role of Ab inhibitory functions besides neutralization. Moreover, Ab isotypes and subclasses recognizing specific HIV envelope epitopes as well as pecular Fc-receptor polymorphisms have been associated with disease progression. These findings further support the need to define which Fc-mediated Ab inhibitory functions leading to protection are critical for HIV vaccine design. Herein, based on our previous review Su & Moog Front Immunol 2014, we update the different inhibitory properties of HIV-specific Abs that may potentially contribute to HIV protection.

Details

Language :
English
ISSN :
16643224
Volume :
10
Database :
OpenAIRE
Journal :
Frontiers in Immunology
Accession number :
edsair.pmid.dedup....ef6f7c5779f2ee05c2a6a1d3fb021e19