Back to Search
Start Over
GWAS of lifetime cannabis use reveals new risk loci, genetic overlap with psychiatric traits, and a causal influence of schizophrenia
- Source :
- Pasman, J A, Verweij, K J H, Gerring, Z, Stringer, S, Sanchez-Roige, S, Treur, J L, Abdellaoui, A, Nivard, M G, Baselmans, B M L, Ong, J-S, Ip, H F, van der Zee, M D, Bartels, M, Day, F R, Fontanillas, P, Elson, S L, de Wit, H, Davis, L K, MacKillop, J, Derringer, J L, Branje, S J T, Hartman, C A, Heath, A C, van Lier, P A C, Madden, P A F, Mägi, R, Meeus, W, Montgomery, G W, Oldehinkel, A J, Pausova, Z, Ramos-Quiroga, J A, Paus, T, Ribases, M, Kaprio, J, Boks, M P M, Bell, J T, Spector, T D, Gelernter, J, Boomsma, D I, Martin, N G, MacGregor, S, Perry, J R B, Palmer, A A, Posthuma, D, Munafò, M R, Gillespie, N A & Derks, E M & Vink, J M 2018, ' GWAS of lifetime cannabis use reveals new risk loci, genetic overlap with psychiatric traits, and a causal influence of schizophrenia ', Nature Neuroscience, vol. 21, no. 9, pp. 1161-1170 . https://doi.org/10.1038/s41593-018-0206-1, Pasman, JA; Verweij, KJH; Gerring, Z; Stringer, S; Sanchez-Roige, S; Treur, JL; et al.(2018). GWAS of lifetime cannabis use reveals new risk loci, genetic overlap with psychiatric traits, and a causal influence of schizophrenia. Nature Neuroscience, 21(9), 1161-1170. doi: 10.1038/s41593-018-0206-1. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/4692767n, Nature neuroscience, 21(9), 1161-1170. NATURE AMERICA INC
- Publication Year :
- 2018
-
Abstract
- © 2018, The Author(s). Cannabis use is a heritable trait that has been associated with adverse mental health outcomes. In the largest genome-wide association study (GWAS) for lifetime cannabis use to date (N = 184,765), we identified eight genome-wide significant independent single nucleotide polymorphisms in six regions. All measured genetic variants combined explained 11% of the variance. Gene-based tests revealed 35 significant genes in 16 regions, and S-PrediXcan analyses showed that 21 genes had different expression levels for cannabis users versus nonusers. The strongest finding across the different analyses was CADM2, which has been associated with substance use and risk-taking. Significant genetic correlations were found with 14 of 25 tested substance use and mental health–related traits, including smoking, alcohol use, schizophrenia and risk-taking. Mendelian randomization analysis showed evidence for a causal positive influence of schizophrenia risk on cannabis use. Overall, our study provides new insights into the etiology of cannabis use and its relation with mental health.
- Subjects :
- Adult
Male
Marijuana Abuse
Adolescent
Genotype
Gene Expression Regulation/genetics
Polymorphism, Single Nucleotide
23andMe Research Team
Article
Schizophrenia/chemically induced
Marijuana Abuse/genetics
Young Adult
Risk-Taking
Databases, Genetic
Taverne
Humans
International Cannabis Consortium
Genetic Predisposition to Disease
Aged
Aged, 80 and over
Mendelian Randomization Analysis
Middle Aged
Mental Health
Gene Expression Regulation
Schizophrenia
Substance Use Disorders Working Group of the Psychiatric Genomics Consortium
Female
Cell Adhesion Molecules/genetics
Cell Adhesion Molecules
Genome-Wide Association Study
Subjects
Details
- Language :
- English
- ISSN :
- 10976256
- Database :
- OpenAIRE
- Journal :
- Pasman, J A, Verweij, K J H, Gerring, Z, Stringer, S, Sanchez-Roige, S, Treur, J L, Abdellaoui, A, Nivard, M G, Baselmans, B M L, Ong, J-S, Ip, H F, van der Zee, M D, Bartels, M, Day, F R, Fontanillas, P, Elson, S L, de Wit, H, Davis, L K, MacKillop, J, Derringer, J L, Branje, S J T, Hartman, C A, Heath, A C, van Lier, P A C, Madden, P A F, Mägi, R, Meeus, W, Montgomery, G W, Oldehinkel, A J, Pausova, Z, Ramos-Quiroga, J A, Paus, T, Ribases, M, Kaprio, J, Boks, M P M, Bell, J T, Spector, T D, Gelernter, J, Boomsma, D I, Martin, N G, MacGregor, S, Perry, J R B, Palmer, A A, Posthuma, D, Munafò, M R, Gillespie, N A & Derks, E M & Vink, J M 2018, ' GWAS of lifetime cannabis use reveals new risk loci, genetic overlap with psychiatric traits, and a causal influence of schizophrenia ', Nature Neuroscience, vol. 21, no. 9, pp. 1161-1170 . https://doi.org/10.1038/s41593-018-0206-1, Pasman, JA; Verweij, KJH; Gerring, Z; Stringer, S; Sanchez-Roige, S; Treur, JL; et al.(2018). GWAS of lifetime cannabis use reveals new risk loci, genetic overlap with psychiatric traits, and a causal influence of schizophrenia. Nature Neuroscience, 21(9), 1161-1170. doi: 10.1038/s41593-018-0206-1. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/4692767n, Nature neuroscience, 21(9), 1161-1170. NATURE AMERICA INC
- Accession number :
- edsair.pmid.dedup....f725447858788a1612f1c29739b39ef8