Identificering og validering af hyppigt forekommende CpG ø hypermethylering i kolorektale adenomer og carcinomer :CpG ø hypermethylering i kolorektal cancer

Authors :: Øster, Bodil
Thorsen, Kasper
Lamy, Philippe
Wojdacz, Tomasz K
Hansen, Lise Lotte
Birkenkamp-Demtröder, Karin
Dalsgaard Sørensen, Karina
Laurberg, Søren
Ørntoft, Torben Falck
Andersen, Claus Lindbjerg
Source :: Øster, B, Thorsen, K, Lamy, P, Wojdacz, T K, Hansen, L L, Birkenkamp-Demtröder, K, Dalsgaard Sørensen, K, Laurberg, S, Ørntoft, T F & Andersen, C L 2011, ' Identification and validation of highly frequent CpG island hypermethylation in colorectal adenomas and carcinomas : CpG island hypermethylation in colorectal cancer ', International Journal of Cancer . https://doi.org/10.1002/ijc.25951
Publication Year :: 2011
Abstract: In the present study, whole-genome methylation arrays were applied to identify novel genes with tumor specific DNA methylation of promoter CpG islands in pre-malignant and malignant colorectal lesions. Using a combination of Illumina HumanMethylation27 beadchips, Methylation-Sensitive High Resolution Melting (MS-HRM) analysis, and Exon arrays (Affymetrix) the DNA methylation pattern of ~14.000 genes and their transcript levels were investigated in six normal mucosas, six adenomas, and 30 MSI and MSS carcinomas. Sixty eight genes with tumor-specific hypermethylation were identified (p

Subjects :: genome-wide
DNA methylation
gene expression
Colorectal cancer
microarray
digestive system diseases

Language :: English
Database :: OpenAIRE
Journal :: Øster, B, Thorsen, K, Lamy, P, Wojdacz, T K, Hansen, L L, Birkenkamp-Demtröder, K, Dalsgaard Sørensen, K, Laurberg, S, Ørntoft, T F & Andersen, C L 2011, ' Identification and validation of highly frequent CpG island hypermethylation in colorectal adenomas and carcinomas : CpG island hypermethylation in colorectal cancer ', International Journal of Cancer . https://doi.org/10.1002/ijc.25951
Accession number :: edsair.pure.au.......136b214aab71b61dc81a42696a4a9de4

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