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Integral Control Feedback Circuit for the Reactivation of Malfunctioning p53 Pathway
- Publication Year :
- 2015
-
Abstract
- We developed a strategy to control p53 levels when the p53 concentration falls below a desired threshold . Based on an established p53-MDM2 mathematical model that also incorporates microRNA regulators (p53-MDM2-miRNA), we applied a control action in closed-loop with respect to this model. In particular, we employ various architectures of synthetic circuit with integral feedback control, illustrating varying degree in adaptive response to step-wise perturbation of p53.<br />Comment: 23 pages. 8 figures. Theoretical model of synthetic circuit that implements integral control feedback
Details
- Database :
- arXiv
- Publication Type :
- Report
- Accession number :
- edsarx.1510.04136
- Document Type :
- Working Paper