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Characterization of SARS-CoV-2 Dynamics in the Host
- Publication Year :
- 2020
-
Abstract
- While many epidemiological models have being proposed to understand and handle COVID-19, too little has been invested to understand how the virus replicates in the human body and potential antiviral can be used to control the replication cycle. In this work, using a control theoretical approach, validated mathematical models of SARS-CoV-2 in humans are properly characterized. A complete analysis of the main dynamic characteristic is developed based on the reproduction number. The equilibrium regions of the system are fully characterized, and the stability of such a regions, formally established. Mathematical analysis highlights critical conditions to decrease monotonically SARS-CoV-2 in the host, such conditions are relevant to tailor future antiviral treatments. Simulation results show the potential benefits of the aforementioned system characterization.
- Subjects :
- Mathematics - Dynamical Systems
Quantitative Biology - Populations and Evolution
Subjects
Details
- Database :
- arXiv
- Publication Type :
- Report
- Accession number :
- edsarx.2006.08447
- Document Type :
- Working Paper