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Probability of symptoms and critical disease after SARS-CoV-2 infection

Authors :
Poletti, Piero
Tirani, Marcello
Cereda, Danilo
Trentini, Filippo
Guzzetta, Giorgio
Sabatino, Giuliana
Marziano, Valentina
Castrofino, Ambra
Grosso, Francesca
Del Castillo, Gabriele
Piccarreta, Raffaella
Force, ATS Lombardy COVID-19 Task
Andreassi, Aida
Melegaro, Alessia
Gramegna, Maria
Ajelli, Marco
Merler, Stefano
Source :
JAMA Netw Open. 2021;4(3):e211085
Publication Year :
2020

Abstract

We quantified the probability of developing symptoms (respiratory or fever \geq 37.5 {\deg}C) and critical disease (requiring intensive care or resulting in death) of SARS-CoV-2 positive subjects. 5,484 contacts of SARS-CoV-2 index cases detected in Lombardy, Italy were analyzed, and positive subjects were ascertained via nasal swabs and serological assays. 73.9% of all infected individuals aged less than 60 years did not develop symptoms (95% confidence interval: 71.8-75.9%). The risk of symptoms increased with age. 6.6% of infected subjects older than 60 years had critical disease, with males at significantly higher risk.<br />Comment: sample increased: results updated with new records coming from the ongoing serological surveys

Details

Database :
arXiv
Journal :
JAMA Netw Open. 2021;4(3):e211085
Publication Type :
Report
Accession number :
edsarx.2006.08471
Document Type :
Working Paper
Full Text :
https://doi.org/10.1001/jamanetworkopen.2021.1085