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Homeostatic and Adaptive Energetics: Nonequilibrium Fluctuations Beyond Detailed Balance in Voltage-Gated Ion Channels
- Publication Year :
- 2022
-
Abstract
- Stochastic thermodynamics has largely succeeded in characterizing both equilibrium and far-from-equilibrium phenomena. Yet many opportunities remain for application to mesoscopic complex systems -- especially biological ones -- whose effective dynamics often violate detailed balance and whose microscopic degrees of freedom are often unknown or intractable. After reviewing excess and housekeeping energetics -- the adaptive and homeostatic components of a system's dissipation -- we extend stochastic thermodynamics with a trajectory class fluctuation theorem for nonequilibrium steady-state, nondetailed-balanced complex systems. We then take up the neurobiological examples of voltage-gated sodium and potassium ion channels to apply and illustrate the theory, elucidating their nonequilibrium behavior under a biophysically plausible action potential drive. These results uncover challenges for future experiments and highlight the progress possible understanding the thermodynamics of complex systems -- without exhaustive knowledge of every underlying degree of freedom.<br />Comment: 17 pages, 9 figures; http://csc.ucdavis.edu/~cmg/compmech/pubs/toic.htm
Details
- Database :
- arXiv
- Publication Type :
- Report
- Accession number :
- edsarx.2202.13038
- Document Type :
- Working Paper
- Full Text :
- https://doi.org/10.1103/PhysRevE.106.044410