Phase transition modelling of relapse in major depressive disorder: Developing and reflecting on an interdisciplinary conceptual translation

A tipping point can be defined as an abrupt shift in the properties or behaviour of a system. Tipping points in complex systems from a wide variety of scientific disciplines have been compared to phase transitions in physics, but consistent methodology for modelling tipping points as phase transitions has been lacking. Here, we propose a systematic approach aimed at order parameter identification in systems outside of physics undergoing an apparent regime shift. Based on classical Landau theory, we assess the relatedness of a system's properties to the order parameter by means of two quantitatively operationalized criteria: (1) the presence of a significant level shift over the course of the tipping point and (2) increased fluctuations before the tipping point. We first demonstrate the feasibility of our method by applying it to a case study of a tipping point in major depressive disorder, resulting in a list of symptoms that are most likely to be closely related to the order parameter in this particular system. Subsequently, we probe the usefulness of our approach in the interdisciplinary context of complexity science by means of exploratory interviews with active scientists. Our results suggest a growing need for interdisciplinary methodologies in complex systems studies, to which the phase transition modelling we present could provide a valuable addition.
Comment: 21 pages, 5 figures, 6 files with supporting information