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Assessing and Enhancing Robustness of Deep Learning Models with Corruption Emulation in Digital Pathology

Authors :
Huang, Peixiang
Zhang, Songtao
Gan, Yulu
Xu, Rui
Zhu, Rongqi
Qin, Wenkang
Guo, Limei
Jiang, Shan
Luo, Lin
Publication Year :
2023

Abstract

Deep learning in digital pathology brings intelligence and automation as substantial enhancements to pathological analysis, the gold standard of clinical diagnosis. However, multiple steps from tissue preparation to slide imaging introduce various image corruptions, making it difficult for deep neural network (DNN) models to achieve stable diagnostic results for clinical use. In order to assess and further enhance the robustness of the models, we analyze the physical causes of the full-stack corruptions throughout the pathological life-cycle and propose an Omni-Corruption Emulation (OmniCE) method to reproduce 21 types of corruptions quantified with 5-level severity. We then construct three OmniCE-corrupted benchmark datasets at both patch level and slide level and assess the robustness of popular DNNs in classification and segmentation tasks. Further, we explore to use the OmniCE-corrupted datasets as augmentation data for training and experiments to verify that the generalization ability of the models has been significantly enhanced.

Details

Database :
arXiv
Publication Type :
Report
Accession number :
edsarx.2310.20427
Document Type :
Working Paper