Navigating the nexus: a perspective of centrosome -cytoskeleton interactions

A structural relationship between the centrosome and cytoskeleton has been recognized for many years. Centrosomes typically reside near the nucleus, establishing and maintaining the nucleus-centrosome axis. This spatial arrangement is critical for determining cell polarity during interphase and ensuring the proper assembly of the spindle apparatus during mitosis. Centrosomes also engage in physical interactions with various components of the cytoskeleton, balancing internal cellular architecture and polarity in a manner specific to tissue type and developmental stage. Numerous crosslinking proteins facilitate these interactions, promoting both cytoskeletal and centrosomal nucleation. This article provides an overview of how cytoskeletal elements and centrosomes coordinate their actions to regulate complex cellular functions such as cell migration, adhesion, and division. The reciprocal influence between cytoskeletal dynamics and centrosomal positioning underscores their integral roles in cellular organization and function.
Comment: 15 pages, 1 Figure