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ProjectedEx: Enhancing Generation in Explainable AI for Prostate Cancer

Authors :
Qi, Xuyin
Zhang, Zeyu
Handoko, Aaron Berliano
Zheng, Huazhan
Chen, Mingxi
Huy, Ta Duc
Phan, Vu Minh Hieu
Zhang, Lei
Cheng, Linqi
Jiang, Shiyu
Zhang, Zhiwei
Liao, Zhibin
Zhao, Yang
To, Minh-Son
Publication Year :
2025

Abstract

Prostate cancer, a growing global health concern, necessitates precise diagnostic tools, with Magnetic Resonance Imaging (MRI) offering high-resolution soft tissue imaging that significantly enhances diagnostic accuracy. Recent advancements in explainable AI and representation learning have significantly improved prostate cancer diagnosis by enabling automated and precise lesion classification. However, existing explainable AI methods, particularly those based on frameworks like generative adversarial networks (GANs), are predominantly developed for natural image generation, and their application to medical imaging often leads to suboptimal performance due to the unique characteristics and complexity of medical image. To address these challenges, our paper introduces three key contributions. First, we propose ProjectedEx, a generative framework that provides interpretable, multi-attribute explanations, effectively linking medical image features to classifier decisions. Second, we enhance the encoder module by incorporating feature pyramids, which enables multiscale feedback to refine the latent space and improves the quality of generated explanations. Additionally, we conduct comprehensive experiments on both the generator and classifier, demonstrating the clinical relevance and effectiveness of ProjectedEx in enhancing interpretability and supporting the adoption of AI in medical settings. Code will be released at https://github.com/Richardqiyi/ProjectedEx

Details

Database :
arXiv
Publication Type :
Report
Accession number :
edsarx.2501.01392
Document Type :
Working Paper