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Oropharyngeal mucosal transmission of Zika virus in rhesus macaques

Authors :
Christina M. Newman
Dawn M. Dudley
Matthew T. Aliota
Andrea M. Weiler
Gabrielle L. Barry
Mariel S. Mohns
Meghan E. Breitbach
Laurel M. Stewart
Connor R. Buechler
Michael E. Graham
Jennifer Post
Nancy Schultz-Darken
Eric Peterson
Wendy Newton
Emma L. Mohr
Saverio Capuano
David H. O’Connor
Thomas C. Friedrich
Source :
Nature Communications, Vol 8, Iss 1, Pp 1-7 (2017)
Publication Year :
2017
Publisher :
Nature Portfolio, 2017.

Abstract

Zika virus (ZIKV) is present in body fluids, including saliva, but transmission risk through mucosal contact is not well known. Here, the authors show that oropharyngeal mucosal infection of macaques with a high ZIKV dose results in viremia, but that transmission risk from saliva of infected animals is low.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
8
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.00564ee8a1ce45af98f5098b776f6d85
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-017-00246-8