Effect of hydroalcoholic extract of cinnamomum zeylanicum on mood in mice

Background and Aim: Mood disorders such as anxiety and depression are among the most common psychiatric disorders worldwide. Existing drug therapies have various side effects on the central nervous system. Cinnamomum zeylanicum is a dietary additive and studies have shown that it has antioxidant, anti-inflammatory, analgesic, and neuroprotective effects. Also, in traditional medicine, the sedative properties of cinnamon against anxiety and obsession have been mentioned. Therefore in this study, the effect of Cinnamomum zeylanicum on mood in mice was investigated. Materials and Methods: In this experimental study, 144 mice weighing 32±4g were divided in two anxiety (Five groups including control, diazepam 2 mg/kg, and three groups of Cinnamomum hydroalcoholic extract 100,200,400 mg/kg, in each test of the elevated plus-maze and Vogel's conflict tests) and depression (Four groups including control and three groups of cinnamon hydroalcoholic extract 100,200,400 mg/kg, in each test of the forced swimming test and tail suspension tests) protocols. Data were analyzed using one-way ANOVA and Tukey’s post-hoc test. P