Back to Search Start Over

Best Practices in the Clinical Management of Progressive Supranuclear Palsy and Corticobasal Syndrome: A Consensus Statement of the CurePSP Centers of Care

Authors :
Brent Bluett
Alexander Y. Pantelyat
Irene Litvan
Farwa Ali
Diana Apetauerova
Danny Bega
Lisa Bloom
James Bower
Adam L. Boxer
Marian L. Dale
Rohit Dhall
Antoine Duquette
Hubert H. Fernandez
Jori E. Fleisher
Murray Grossman
Michael Howell
Diana R. Kerwin
Julie Leegwater-Kim
Christiane Lepage
Peter Alexander Ljubenkov
Martina Mancini
Nikolaus R. McFarland
Paolo Moretti
Erica Myrick
Pritika Patel
Laura S. Plummer
Federico Rodriguez-Porcel
Julio Rojas
Christos Sidiropoulos
Miriam Sklerov
Leonard L. Sokol
Paul J. Tuite
Lawren VandeVrede
Jennifer Wilhelm
Anne-Marie A. Wills
Tao Xie
Lawrence I. Golbe
Source :
Frontiers in Neurology, Vol 12 (2021)
Publication Year :
2021
Publisher :
Frontiers Media S.A., 2021.

Abstract

Progressive supranuclear palsy (PSP) and corticobasal syndrome (CBS; the most common phenotype of corticobasal degeneration) are tauopathies with a relentless course, usually starting in the mid-60s and leading to death after an average of 7 years. There is as yet no specific or disease-modifying treatment. Clinical deficits in PSP are numerous, involve the entire neuraxis, and present as several discrete phenotypes. They center on rigidity, bradykinesia, postural instability, gait freezing, supranuclear ocular motor impairment, dysarthria, dysphagia, incontinence, sleep disorders, frontal cognitive dysfunction, and a variety of behavioral changes. CBS presents with prominent and usually asymmetric dystonia, apraxia, myoclonus, pyramidal signs, and cortical sensory loss. The symptoms and deficits of PSP and CBS are amenable to a variety of treatment strategies but most physicians, including many neurologists, are reluctant to care for patients with these conditions because of unfamiliarity with their multiplicity of interacting symptoms and deficits. CurePSP, the organization devoted to support, research, and education for PSP and CBS, created its CurePSP Centers of Care network in North America in 2017 to improve patient access to clinical expertise and develop collaborations. The directors of the 25 centers have created this consensus document outlining best practices in the management of PSP and CBS. They formed a writing committee for each of 12 sub-topics. A 4-member Steering Committee collated and edited the contributions. The result was returned to the entire cohort of authors for further comments, which were considered for incorporation by the Steering Committee. The authors hope that this publication will serve as a convenient guide for all clinicians caring for patients with PSP and CBS and that it will improve care for patients with these devastating but manageable disorders.

Details

Language :
English
ISSN :
16642295
Volume :
12
Database :
Directory of Open Access Journals
Journal :
Frontiers in Neurology
Publication Type :
Academic Journal
Accession number :
edsdoj.0194e9bab8b847dbbb83615232a6e800
Document Type :
article
Full Text :
https://doi.org/10.3389/fneur.2021.694872