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A unified route for flavivirus structures uncovers essential pocket factors conserved across pathogenic viruses

Authors :
Joshua M. Hardy
Natalee D. Newton
Naphak Modhiran
Connor A. P. Scott
Hariprasad Venugopal
Laura J. Vet
Paul R. Young
Roy A. Hall
Jody Hobson-Peters
Fasséli Coulibaly
Daniel Watterson
Source :
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Publication Year :
2021
Publisher :
Nature Portfolio, 2021.

Abstract

Understanding virus assembly could identify potential drug targets. Here the authors use a safe and efficient method to solve pathogenic flavivirus structures, revealing two lipid-like ligands within highly conserved pockets of the stem region of envelope protein that are important for virus maturation.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
12
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.01baa3c70744276b2e3dffa7df9e256
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-021-22773-1