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Accelerating the Development of Measles and Rubella Microarray Patches to Eliminate Measles and Rubella: Recent Progress, Remaining Challenges

Authors :
Mateusz Hasso-Agopsowicz
Natasha Crowcroft
Robin Biellik
Christopher J. Gregory
Marion Menozzi-Arnaud
Jean-Pierre Amorij
Philippe-Alexandre Gilbert
Kristen Earle
Collrane Frivold
Courtney Jarrahian
Mercy Mvundura
Jessica J. Mistilis
David N. Durrheim
Birgitte Giersing
Source :
Frontiers in Public Health, Vol 10 (2022)
Publication Year :
2022
Publisher :
Frontiers Media S.A., 2022.

Abstract

Measles and rubella microarray patches (MR-MAPs) are critical in achieving measles and rubella eradication, a goal highly unlikely to meet with current vaccines presentations. With low commercial incentive to MAP developers, limited and uncertain funding, the need for investment in a novel manufacturing facility, and remaining questions about the source of antigen, product demand, and regulatory pathway, MR-MAPs are unlikely to be prequalified by WHO and ready for use before 2033. This article describes the current progress of MR-MAPs, highlights challenges and opportunities pertinent to MR-MAPs manufacturing, regulatory approval, creating demand, and timelines to licensure. It also describes activities that are being undertaken by multiple partners to incentivise investment in and accelerate the development of MR-MAPs.

Details

Language :
English
ISSN :
22962565
Volume :
10
Database :
Directory of Open Access Journals
Journal :
Frontiers in Public Health
Publication Type :
Academic Journal
Accession number :
edsdoj.01d9af75e3564539891d382ee5eb5650
Document Type :
article
Full Text :
https://doi.org/10.3389/fpubh.2022.809675