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Association of Apolipoprotein E Alleles with Susceptibility to Age-Related Macular Degeneration in Iranian Patients
- Source :
- Research in Molecular Medicine, Vol 3, Iss 2, Pp 22-27 (2015)
- Publication Year :
- 2015
- Publisher :
- Mazandaran University of Medical Sciences and Health Services, 2015.
-
Abstract
- Background: We aimed here to investigate the association between alleles and genotypes of APOE and Age-related macular degeneration (AMD) development. Materials and Methods: After ophthalmological examination, 120 patients with confirmed AMD and 120 healthy controls were enrolled in the study. The polymorphic segment of APOE gene was PCR-amplified and sequenced to determine the frequency distribution of polymorphic alleles and genotypes of this gene in the sample population. Results: The frequency distribution of APOE alleles and genotypes differed significantly between the patients and the control groups (P
Details
- Language :
- English
- ISSN :
- 23221348 and 2322133X
- Volume :
- 3
- Issue :
- 2
- Database :
- Directory of Open Access Journals
- Journal :
- Research in Molecular Medicine
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.0298d2e7d25d45269df4daa005d759fe
- Document Type :
- article