O-GlcNAc transferase inhibits visceral fat lipolysis and promotes diet-induced obesity

Authors :: Yunfan Yang
Minnie Fu
Min-Dian Li
Kaisi Zhang
Bichen Zhang
Simeng Wang
Yuyang Liu
Weiming Ni
Qunxiang Ong
Jia Mi
Xiaoyong Yang
Source :: Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Publication Year :: 2020
Publisher :: Nature Portfolio, 2020.
Abstract: Post-translational O-linked β-N acetylglucosamine (O-GlcNAc) modification acts as a nutrient-sensing mechanism. Here the authors report that O-GlcNAc transferase inhibits adipose tissue lipolysis via O-GlcNAcylation of the lipid droplet protein perilipin 1 and thus promotes diet-induced obesity.

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