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Dissecting the molecular evolution of fluoroquinolone-resistant Shigella sonnei

Authors :
Hao Chung The
Christine Boinett
Duy Pham Thanh
Claire Jenkins
Francois-Xavier Weill
Benjamin P. Howden
Mary Valcanis
Niall De Lappe
Martin Cormican
Sonam Wangchuk
Ladaporn Bodhidatta
Carl J. Mason
To Nguyen Thi Nguyen
Tuyen Ha Thanh
Vinh Phat Voong
Vu Thuy Duong
Phu Huong Lan Nguyen
Paul Turner
Ryan Wick
Pieter-Jan Ceyssens
Guy Thwaites
Kathryn E. Holt
Nicholas R. Thomson
Maia A. Rabaa
Stephen Baker
Source :
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Publication Year :
2019
Publisher :
Nature Portfolio, 2019.

Abstract

Shigella sonnei is one of the main species causing shigellosis worldwide. Here the authors analyse nearly 400 S. sonnei genome sequences and carry out experimental evolution experiments to shed light into the evolutionary processes underlying the recent emergence of fluoroquinolone resistance in this pathogen.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
10
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.02e39349172244c286f76e940e3e3054
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-019-12823-0