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Sinus arrhythmia caused by pemetrexed with carboplatin combination: A case report

Sinus arrhythmia caused by pemetrexed with carboplatin combination: A case report

Authors :
Xianghua Quan
Haonan Zhang
Wen Xu
Mengna Cui
Qie Guo
Source :
Heliyon, Vol 8, Iss 10, Pp e11006- (2022)
Publication Year :
2022
Publisher :
Elsevier, 2022.

Abstract

Combination chemotherapy of pemetrexed and carboplatin is a standard treatment approach for non-small cell lung cancer (NSCLC). However, no prior reports have described cardiotoxicity associated with this therapeutic combination or sinus arrhythmia in oncological contexts. Here, we report the case of a 44-year-old female NSCLC patient that suffered from sinus arrhythmia following combined chemotherapeutic treatment with pemetrexed and carboplatin. The patient was successfully treated under medical guidance, and the condition was effectively reversed following the discontinuation of this chemotherapeutic regimen and medication prescribing. Overall, this represents a rare case of sinus arrhythmia in NSCLC patient during the first cycle of combined chemotherapy with pemetrexed and carboplatin. However, a putative etiological basis for this rare clinical entity remains to be established.

Details

Language :
English
ISSN :
24058440
Volume :
8
Issue :
10
Database :
Directory of Open Access Journals
Journal :
Heliyon
Publication Type :
Academic Journal
Accession number :
edsdoj.033ac4cf4c644bf87b94e1fecfc48d3
Document Type :
article
Full Text :
https://doi.org/10.1016/j.heliyon.2022.e11006