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Prospective effects of cholecalciferol supplementation on irisin levels in sedentary postmenopausal women: A pilot study

Authors :
Luiz Phellipe Dell Aquila
Armando Morales
Patricia Moreira
Maysa Seabra Cendoroglo
Rosilene Motta Elias
Maria Aparecida Dalboni
Source :
Journal of Clinical & Translational Endocrinology, Vol 34, Iss , Pp 100324- (2023)
Publication Year :
2023
Publisher :
Elsevier, 2023.

Abstract

Introduction: In postmenopausal women, vitamin D deficiency has been associated with disability, low muscle mass and fractures. Irisin is an important myokine that may contribute to the maintenance of muscle and bone density. Vitamin D is associated with the growth and function of muscle tissue through interactions between the vitamin D receptor and PGC-1α and activation of p38/MAPK (mitogen-activated protein kinase) in muscle, a mechanism similar to irisin action. The aim of this pilot study was to evaluate the effects of cholecalciferol supplementation on serum irisin levels in sedentary postmenopausal women with hypovitaminosis D (25(OH)D

Details

Language :
English
ISSN :
22146237
Volume :
34
Issue :
100324-
Database :
Directory of Open Access Journals
Journal :
Journal of Clinical & Translational Endocrinology
Publication Type :
Academic Journal
Accession number :
edsdoj.037ca4701970412e9aaa63abc1c633bc
Document Type :
article
Full Text :
https://doi.org/10.1016/j.jcte.2023.100324