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Case Report: Possible autoimmune obsessive-compulsive disorder with postpartum onset

Authors :
Dominique Endres
Luciana Hannibal
Benjamin Zaltenbach
Miriam A. Schiele
Kimon Runge
Kathrin Nickel
Benjamin Berger
Katharina Domschke
Nils Venhoff
Harald Prüss
Ludger Tebartz van Elst
Source :
Frontiers in Immunology, Vol 13 (2022)
Publication Year :
2022
Publisher :
Frontiers Media S.A., 2022.

Abstract

Autoimmune obsessive–compulsive disorder (OCD) is rare. The case presented here is that of a female patient in her mid-thirties who developed postpartum OCD. Magnetic resonance imaging showed multiple juxtacortical hyperintensities that may have been post-inflammatory in origin. In tissue-based assays using mouse brain slices, the patient’s cerebrospinal fluid (CSF) showed novel anti-nucleoli autoantibodies in cerebellar Purkinje cells and cortical neurons. The CSF dopamine and glutamate concentrations were dysregulated. The clinical course and diagnostic findings were compatible with possible autoimmune OCD with postpartum onset.

Details

Language :
English
ISSN :
16643224
Volume :
13
Database :
Directory of Open Access Journals
Journal :
Frontiers in Immunology
Publication Type :
Academic Journal
Accession number :
edsdoj.03993f23498492e917666eaf3eb2285
Document Type :
article
Full Text :
https://doi.org/10.3389/fimmu.2022.970448