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Altered resting-state cerebellar-cerebral functional connectivity in patients with end-stage renal disease
- Source :
- Renal Failure, Vol 45, Iss 1 (2023)
- Publication Year :
- 2023
- Publisher :
- Taylor & Francis Group, 2023.
-
Abstract
- AbstractBackground End-stage renal disease (ESRD) patients have functional and structural brain abnormalities. The cerebellum also showed varying degrees of damage. However, no studies on cerebellar-cerebral functional connectivity (FC) have been conducted in ESRD patients. This study aimed to investigate the changes in cerebellar-cerebral FC in ESRD patients and its relationship with neuropsychological and clinical indexes.Methods Resting-state functional magnetic resonance imaging and neuropsychological assessment were performed on 37 ESRD patients and 35 control subjects. Seed-based FC analysis was performed to investigate inter-group differences in cerebellar-cerebral FC. In addition, the relations of altered FC with the neuropsychological function and clinical indicators were analyzed in ERSD patients.Results ESRD patients exhibited alterations in cerebellar-cerebral FC involving the executive control network, default mode network, and affective-limbic network compared to control subjects (False discovery rate-corrected, p
Details
- Language :
- English
- ISSN :
- 0886022X and 15256049
- Volume :
- 45
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Renal Failure
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.03b491200d2e432b897ca0c097b3288f
- Document Type :
- article
- Full Text :
- https://doi.org/10.1080/0886022X.2023.2238829