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Kiwifruit with high anthocyanin content modulates NF-κB activation and reduces CCL11 secretion in human alveolar epithelial cells
- Source :
- Journal of Functional Foods, Vol 65, Iss , Pp 103734- (2020)
- Publication Year :
- 2020
- Publisher :
- Elsevier, 2020.
-
Abstract
- Asthma is an allergic lung inflammation characterised by the influx of eosinophils at the infected site recruited by the chemokine, CCL11. During inflammation, the transcription factor Nuclear Factor kappa B (NF-κB) initiates a series of pro-inflammatory responses. Natural compounds that could modulate CCL11 levels and/or NF-κB activation have potential for managing lung inflammation. In this study, four varieties of kiwifruit were evaluated for their modulatory effect on inflammation signals. The anthocyanin-enriched polyphenol extracts from purple kiwifruit inhibited CCL11 secretion from human alveolar epithelial cells whereas the anthocyanin-lacking polyphenol extracts from yellow kiwifruit displayed no inhibition on CCL11 secretion. Kiwifruit polyphenol extracts also inhibited NF-κB activation in reporter cells. Correlation analysis showed anthocyanins in the kiwifruit polyphenolic extracts were most correlated to the modulation of CCL11 and NF-κB which are the inflammatory signals involved in lung allergic inflammation. The findings highlight the enhanced functional food benefits of novel kiwifruit cultivars.
Details
- Language :
- English
- ISSN :
- 17564646
- Volume :
- 65
- Issue :
- 103734-
- Database :
- Directory of Open Access Journals
- Journal :
- Journal of Functional Foods
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.03dc981a858b47f796527a6b79ceb047
- Document Type :
- article
- Full Text :
- https://doi.org/10.1016/j.jff.2019.103734