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Epigenetic homogeneity in histone methylation underlies sperm programming for embryonic transcription

Authors :
Mami Oikawa
Angela Simeone
Eva Hormanseder
Marta Teperek
Vincent Gaggioli
Alan O’Doherty
Emma Falk
Matthieu Sporniak
Clive D’Santos
Valar Nila Roamio Franklin
Kamal Kishore
Charles R. Bradshaw
Declan Keane
Thomas Freour
Laurent David
Adrian T. Grzybowski
Alexander J. Ruthenburg
John Gurdon
Jerome Jullien
Source :
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Publication Year :
2020
Publisher :
Nature Portfolio, 2020.

Abstract

In addition to paternal genetic material, sperm contributes epigenetic information to the embryo to efficiently support development. Here, the authors demonstrate a homogeneous paternal contribution to epigenetic information via sperm-derived modified histone transmission to the developing vertebrate embryo.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
11
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.043134247e74f1c9eff413a64d36d41
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-020-17238-w