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High level of psychological stress in COVID-19 recovered individuals: role of copeptin as a potential biomarker
- Source :
- Frontiers in Psychology, Vol 14 (2023)
- Publication Year :
- 2023
- Publisher :
- Frontiers Media S.A., 2023.
-
Abstract
- BackgroundStudy aimed to assess stress in COVID-19 recovered individuals using a validated questionnaire PSS-10 score and stress biomarkers – salivary cortisol and serum copeptin.MethodsA total of 83 subjects of which 54 subjects (66.3%) who were hospitalized were recruited 8–20 weeks following recovery from COVID-19. Stress was assessed by PSS-10 stress-scale after a mean duration of 14.5 weeks after recovery. Sixty-eight subjects (81.9%) had new or persistent symptoms after recovery. Subjects were divided into two groups on the basis of PSS score; mild stress (PSS:0–13) and moderate to severe stress (PSS:>14) and levels of biomarkers (serum copeptin, DHEAS and salivary cortisol) were compared in the two groups.ResultsForty-four subjects (53%) had moderate to severe stress and 39 subjects (47%) had mild stress. Subjects with post COVID symptoms had significantly higher stress levels as compared to subjects who were asymptomatic [15 vs. 9; p = 0.003]. Serum copeptin levels were significantly higher among subjects with moderate to severe stress as compared to those with mild stress [0.41 vs. 0.67 ng/mL; p = 0.031]. Subjects with moderate to severe stress had higher median salivary cortisol compared to subjects with mild stress [1.03 vs. 1.44 nmol/L; p = 0.448].ConclusionOur study demonstrated moderate to severe stress in over half and some level of stress in nearly all COVID recovered individuals even after 3 months. Serum copeptin was found to be a useful biomarker to objectively measure stress in these subjects.
Details
- Language :
- English
- ISSN :
- 16641078
- Volume :
- 14
- Database :
- Directory of Open Access Journals
- Journal :
- Frontiers in Psychology
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.046748afbe4b4f44a2e3a8b7e6432c50
- Document Type :
- article
- Full Text :
- https://doi.org/10.3389/fpsyg.2023.1253396