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MAIT cells protect against pulmonary Legionella longbeachae infection

Authors :
Huimeng Wang
Criselle D’Souza
Xin Yi Lim
Lyudmila Kostenko
Troi J. Pediongco
Sidonia B. G. Eckle
Bronwyn S. Meehan
Mai Shi
Nancy Wang
Shihan Li
Ligong Liu
Jeffrey Y. W. Mak
David P. Fairlie
Yoichiro Iwakura
Jennifer M. Gunnersen
Andrew W. Stent
Dale I. Godfrey
Jamie Rossjohn
Glen P. Westall
Lars Kjer-Nielsen
Richard A. Strugnell
James McCluskey
Alexandra J. Corbett
Timothy S. C. Hinks
Zhenjun Chen
Source :
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Publication Year :
2018
Publisher :
Nature Portfolio, 2018.

Abstract

Mucosal associated invariant T (MAIT) cells have been implicated in antibacterial responses. Here the authors show MAIT cells confer IFN-γ-mediated protection from lethal infection in a mouse model of Legionella infection, which can be enhanced by synthetic MR1 ligands.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
9
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.04a7234e223649d8b39e28253a1e7287
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-018-05202-8