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AN1-type zinc finger protein 3 (ZFAND3) is a transcriptional regulator that drives Glioblastoma invasion

Authors :
Anne Schuster
Eliane Klein
Virginie Neirinckx
Arnon Møldrup Knudsen
Carina Fabian
Ann-Christin Hau
Monika Dieterle
Anais Oudin
Petr V. Nazarov
Anna Golebiewska
Arnaud Muller
Daniel Perez-Hernandez
Sophie Rodius
Gunnar Dittmar
Rolf Bjerkvig
Christel Herold-Mende
Barbara Klink
Bjarne Winther Kristensen
Simone P. Niclou
Source :
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Publication Year :
2020
Publisher :
Nature Portfolio, 2020.

Abstract

Glioblastomas (GBMs) are highly invasive brain tumours, but the underlying mechanisms of GBM invasion are unclear. Here, the authors perform an RNA interference screen and identify AN1-Type Zinc Finger protein 3 (ZFAND3) as a regulator of GBM invasion, and find that it acts through the transcriptional regulation of invasion-related genes.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
11
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.04ea0e869f414c02aaa7957879d7374d
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-020-20029-y