Back to Search Start Over

Chemical combinations potentiate human pluripotent stem cell-derived 3D pancreatic progenitor clusters toward functional β cells

Authors :
Haisong Liu
Ronghui Li
Hsin-Kai Liao
Zheying Min
Chao Wang
Yang Yu
Lei Shi
Jiameng Dan
Alberto Hayek
Llanos Martinez Martinez
Estrella Nuñez Delicado
Juan Carlos Izpisua Belmonte
Source :
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Publication Year :
2021
Publisher :
Nature Portfolio, 2021.

Abstract

Human pluripotent stem cell (hPSC) derived pancreatic beta cells are a promising and potentially limitless source for cell replacement therapy. Here the authors perform stage-wise chemical screening to develop an improved protocol for hPSC differentiation to functional pancreatic beta cells at high efficiency.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
12
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.0538b6a302e489391b9de003c23bba8
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-021-23525-x