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Evaluation of serum pro/anti-angiogenic biomarkers in hyperglycemic rats treated with Securigera securidaca seeds, alone and in combination with Glibenclamide

Authors :
Elham Bahreini
Mohammad Babaei
Forogh Mohammadi
Shahin Alizadeh-Fanalou
Source :
Journal of Cardiovascular and Thoracic Research, Vol 16, Iss 1, Pp 8-14 (2024)
Publication Year :
2024
Publisher :
Tabriz University of Medical Sciences, 2024.

Abstract

Introduction: Herbal medicines are commonly used by many people with diabetes in addition to standard treatment. Plants contain numerous known and unknown compounds that may exacerbate or ameliorate diabetes complications. Therefore, it is crucial to be aware of the side effects of these herbs before prescribing them. This study aimed to investigate the effects of hydroalcoholic extracts of Securigera securidaca (HESS) seeds alone and in combination with glibenclamide on the angiogenic/anti-angiogenic balance in streptozotocin (STZ)-induced diabetic rats. Methods: Groups involved in this animal study included diabetic and healthy controls, three doses of HESS, glibenclamide, and combination therapy. Serum samples were collected and analyzed for a vascular endothelial growth factor (VEGF), fibroblast growth factor 21 (FGF21), fetal liver kinase 1 (FLK-1), soluble fms-like tyrosine kinase 1 (sFLT-1), and transforming growth factor -beta (TGF-β). Results: Induction of diabetes increased VEGF, FGF21, and TGF-β serum levels and decreased circulating FLK-1 and sFLT-1 factors. Herbal extract, except TGF-β, had little effect on the above blood levels even at the highest doses. Glibenclamide was more effective than the highest dose of HESS in improving the vascular complications of diabetes. Combination therapy with the highest dose of HESS partly enhanced the glibenclamide effects. Conclusion: Compared with glibenclamide as a standard chemical drug, HESS had no significant effects on the blood levels of the pro/anti-angiogenesis factor in diabetic rats. Glibenclamide attenuated the levels of the biomarkers and its effects were somewhat enhanced in combination with the highest dose of HESS.

Details

Language :
English
ISSN :
20085117 and 20086830
Volume :
16
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Journal of Cardiovascular and Thoracic Research
Publication Type :
Academic Journal
Accession number :
edsdoj.054310f6d2c4c90a38568095cebde50
Document Type :
article
Full Text :
https://doi.org/10.34172/jcvtr.32960