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Real-Time Dual-Wavelength Time-Resolved Diffuse Optical Tomography System for Functional Brain Imaging Based on Probe-Hosted Silicon Photomultipliers

Authors :
David Orive-Miguel
Laura Di Sieno
Anurag Behera
Edoardo Ferocino
Davide Contini
Laurent Condat
Lionel Hervé
Jérôme Mars
Alessandro Torricelli
Antonio Pifferi
Alberto Dalla Mora
Source :
Sensors, Vol 20, Iss 10, p 2815 (2020)
Publication Year :
2020
Publisher :
MDPI AG, 2020.

Abstract

Near-infrared diffuse optical tomography is a non-invasive photonics-based imaging technology suited to functional brain imaging applications. Recent developments have proved that it is possible to build a compact time-domain diffuse optical tomography system based on silicon photomultipliers (SiPM) detectors. The system presented in this paper was equipped with the same eight SiPM probe-hosted detectors, but was upgraded with six injection fibers to shine the sample at several points. Moreover, an automatic switch was included enabling a complete measurement to be performed in less than one second. Further, the system was provided with a dual-wavelength (670 n m and 820 n m ) light source to quantify the oxy- and deoxy-hemoglobin concentration evolution in the tissue. This novel system was challenged against a solid phantom experiment, and two in-vivo tests, namely arm occlusion and motor cortex brain activation. The results show that the tomographic system makes it possible to follow the evolution of brain activation over time with a 1 s -resolution.

Details

Language :
English
ISSN :
14248220
Volume :
20
Issue :
10
Database :
Directory of Open Access Journals
Journal :
Sensors
Publication Type :
Academic Journal
Accession number :
edsdoj.0554f3550ad4057b9617f23c0bee02b
Document Type :
article
Full Text :
https://doi.org/10.3390/s20102815